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Table of Contents
Vol. 35, Suppl. 1, 2001
Issue release date: 2001
Caries Res 2001;35(suppl 1):65–70
(DOI:10.1159/000049114)

Antimicrobial Activity of Fluoride and Its in vivo Importance: Identification of Research Questions

van Loveren C.
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Abstract

This manuscript discusses the antimicrobial activity of fluoride and its in vivo importance in order to identify research questions. There is a lot of information on mechanisms by which fluoride may interfere with bacterial metabolism and dental plaque acidogenicity. The antimicrobial activity of fluoride products is enhanced when fluoride is associated with antimicrobial cations like Sn2+ and amine. It is not clear whether the antimicrobial mechanisms of fluoride are operating in vivo or even to what extent antimicrobial activity can contribute to caries prevention. This latter question may be the most important one in research.



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