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Table of Contents
Vol. 15, No. 2, 2002
Issue release date: March–April 2002
Section title: Original Research Article
Skin Pharmacol Appl Skin Physiol 2002;15:85–91
(DOI:10.1159/000049394)

Different Skin Thinning Potential of Equipotent Medium-Strength Glucocorticoids

Korting H.C. · Unholzer A. · Schäfer-Korting M. · Tausch I. · Gassmueller J. · Nietsch K.-H.
aKlinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität, Munich; bInstitut für Pharmazie, Freie Universität, Berlin; cBioSkin Institut für Dermatologische Forschung und Entwicklung GmbH, Hamburg, and dAventis Pharma Deutschland GmbH, Bad Soden, Germany

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Published online: 2/28/2002

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 0

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP

Abstract

In this study, we investigated the effect of prednicarbate, mometasone furoate and betamethasone 17-valerate on total skin thickness over a treatment period of 6 weeks. The study was conducted as a double-blind, placebo-controlled randomized clinical trial with a confirmatory approach. The influence of these drugs on healthy human skin under non-occlusive conditions was assessed by measuring total skin thickness and epidermal thickness using 20 and 50 MHz sonography, respectively. Epidermal surface structure was evaluated using profilometry. Visual assessment addressed signs of atrophy and formation of telangiectasia. The reduction of total skin thickness induced by prednicarbate was clearly less than that caused by betamethasone 17-valerate and mometasone furoate. Prednicarbate led to a higher degree of skin thinning than vehicle. For technical reasons, epidermal thickness could not be reliably evaluated with 50 MHz sonography. Profilometry did not demonstrate any differences between treatments. Visible signs of atrophy or telangiectasia were detected in two subjects each upon betamethasone 17-valerate and mometasone furoate, but not upon prednicarbate or its vehicle. Prednicarbate is a topical glucocorticoid with an improved benefit/risk ratio, as it causes less skin atrophy than the equipotent betamethasone 17-valerate.


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Published online: 2/28/2002

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 0

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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