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Vol. 53, No. 1, 2002
Issue release date: January 2002
Gynecol Obstet Invest 2002;53:22–27

Recurrence Risk of Preterm Birth due to Preeclampsia

Koike T. · Minakami H. · Izumi A. · Watanabe T. · Matsubara S. · Sato I.
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There may be an increased risk of preterm birth due to preeclampsia among women whose previous pregnancies ended in preterm birth due to preeclampsia. We studied 1,130 women who delivered 2 successive singleton infants in our hospital, excluding women who delivered an abnormally formed infant during the study period. We reviewed the gestational week at delivery in these 2,260 pregnancies and found a total of 182 preterm deliveries (8.1%) by 156 women. The causes of preterm birth were reviewed. Failed tocolysis, including premature rupture of membranes and clinical chorioamnionitis, and preeclampsia accounted for 135 (74.2%) and 30 (16.5%) of the 182 preterm deliveries, respectively. Women whose 1st delivery was preterm had a 3.26 times (95% CI 2.21–4.79) higher risk of a subsequent preterm delivery than women whose 1st delivery was term (26/96 vs. 60/1,034). The risk of preeclampsia-related preterm delivery was 54.4 times (17.2 to 172.5) higher in women with a previous preeclampsia-related preterm delivery than in women with a previous term delivery (5/19 vs. 5/1034). Women who had a history of preeclampsia-related preterm birth had a greater risk of preeclampsia-related preterm birth in a subsequent pregnancy as compared with women with a previous term birth.

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  1. Minakami H, Kimura H, Honma Y, Tamada T, Sato I: When is the optimal time for delivery ? – Purely from the fetuses’ perspective. Gynecol Obstet Invest 1995;40:174–178.
  2. Minakami H, Sato I: Reestimating date of delivery in multifetal pregnancies. JAMA 1996;275:1432–1434.
  3. Kuban KCK, Leviton A: Cerebral palsy. N Engl J Med 1994;330:188–195.
  4. Pharoah POD, Cooke T, Johnson MA, King R, Mutch L: Epidemiology of cerebral palsy in England and Scotland, 1984–9. Arch Dis Child Fetal Neonatal Ed 1998;79:21–25.
  5. Carr-Hill, Hall MH: The repetition of spontaneous preterm labour. Br J Obstet Gynaecol 1985;92:921–928.

    External Resources

  6. Adams MM, Elam-Evans LD, Wilson HG, Gilbertz DA: Rates of and factors associated with recurrence of preterm delivery. JAMA 2000;283:1591–1596.
  7. Hillier SL, Martius J, Krohn M, Kiviat N, Holmes KK, Eschenbach DA: A case-control study of chorioamniotic infection and histologic chorioamnionitis in prematurity. N Engl J Med 1988;319:972–978.
  8. Meis PJ, Ernest JM, Moore ML: Causes of low birth weight births in public and private patients. Am J Obstet Gynecol 1987;156:1165–1168.

    External Resources

  9. Savitz DA, Blackmore CA, Thorp JM: Epidemiologic characteristics of preterm delivery: Etiologic heterogeneity. Am J Obstet Gynecol 1991;164:467–471.
  10. Meis PJ, Michielutte R, Peters TJ, Wells HB, Sands RE, Coles EC, Johns KA: Factors associated with preterm birth in Cardiff, Wales. I. Univariable and multivariable analysis. Am J Obstet Gynecol 1995;173:590–596.
  11. Mercer BM, Goldenberg RL, Moawad AH, Meis PJ, Iams JD, Das AF, Caritis SN, Miodovnik M, Menard MK, Thurnau GR, Dombrowski MP, Roberts JM, McNellis D: The preterm prediction study: Effect of gestational age and cause of preterm birth on subsequent obstetric outcome. Am J Obstet Gynecol 1999;181:1216–1221.
  12. Sibai BM, El-Nazer A, Gonzalez-Ruiz A: Severe preeclampsia-eclampsia in young primigravid women: Subsequent pregnancy outcome and remote prognosis. Am J Obstet Gynecol 1986;155:1011–1016.

    External Resources

  13. Lindeberg S, Axelsson O, Jorner U, Malmberg L, Sandstrom B: A prospective controlled five-year follow-up study of primiparas with gestational hypertension. Acta Obstet Gynecol Scand 1988;67:605–609.

    External Resources

  14. Sibai BM, Mercer B, Sarinoglu C: Severe preeclampsia in the second trimester: Recurrence risk and long-term prognosis. Am J Obstet Gynecol 1991;165:1408–1412.

    External Resources

  15. Makkonen N, Heinonen S, Kirkinen P: Obstetric prognosis in second pregnancy after preeclampsia in first pregnancy. Hypertens Pregnancy 2000;19:173–181.
  16. Campbell DM, MacGillivray I: Preeclampsia in second pregnancy. Br J Obstet Gynaecol 1985;92:131–140.

    External Resources

  17. Dekker GA, de Vries JIP, Doelitzsch PM, Huijgens PC, von Blomberg BME, Jakobs C, van Geijn HP: Underlying disorders associated with severe early-onset preeclampsia. Am J Obstet Gynecol 1995;173:1042–1048.
  18. Van Pampus MG, Dekker GA, Wolf H, Huijgens PC, Koopman MMW, von Blomberg BME, Buller HR: High prevalence of hemostatic abnormalities in women with a history of severe preeclampsia. Am J Obstet Gynecol 1999;180:1146–1150.

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