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Table of Contents
Vol. 40, No. 2, 2001
Issue release date: August 2001
Section title: Prostate Cancer
Eur Urol 2001;40:124–129
(DOI:10.1159/000049761)

Transrectal High Intensity Focused Ultrasound for the Treatment of Localized Prostate Cancer: Factors Influencing the Outcome

Gelet A. · Chapelon J.Y. · Bouvier R. · Rouvière O. · Lyonnet D. · Dubernard J.M.
aUrology Department, Edouard Herriot Hospital, and bINSERM Unit 281, Lyon, France

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Article / Publication Details

First-Page Preview
Abstract of Prostate Cancer

Published online: 10/19/2001

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 2

ISSN: 0302-2838 (Print)
eISSN: 1421-993X (Online)

For additional information: http://www.karger.com/EUR

Abstract

Objectives: Efficacy evaluation of high intensity focused ultrasound (HIFU) treatment for localized prostate cancer and identification of the factors affecting the outcome. Patients and Methods: 102 patients with prostate cancer stage T1–T2 and noncandidates for radical prostatectomy have been treated with HIFU (Ablatherm™, EDAP–Technomed). The disease progression (failure) was strictly defined by any positive sample at control biopsies, whatever the prostate–specific antigen (PSA) level, or by 3 consecutive increases in PSA levels in case of negative biopsies. Results: At inclusion, patients’ baseline characteristics were (mean ± standard deviation): age 70.8 (±6.13) years, PSA 8.38 (±4.8) ng/ml, prostate volume 33.3 (±16.71) cm3. The population mean follow–up was 19 months (3–76 months). The overall success rate was 66%. Statistically significant variations of the overall success with a more favorable outcome were observed when (1) the initial PSA level was ≤10 ng/ml (73 vs. 50%, p = 0.02), (2) the Gleason score was ≤6 (81 vs. 46%, p<0.001) and (3) the pretreatment sextant biopsy evidenced 1–4 positive samples (68 vs. 40%, p = 0.01). Conclusion: Results observed after HIFU treatment in localized prostate cancer are now challenging those obtained after radiation therapy. The success rate is influenced by disease–related prognostic factors.


Article / Publication Details

First-Page Preview
Abstract of Prostate Cancer

Published online: 10/19/2001

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 2

ISSN: 0302-2838 (Print)
eISSN: 1421-993X (Online)

For additional information: http://www.karger.com/EUR


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