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Background: We present a 12-year-old girl with a 5-year history of progressive virilization. Results: Regarding elevated plasma levels of 17-hydroxyprogesterone (17-OHP) and androgens, normal ultrasound and CT scan of ovaries and adrenal glands, the nonclassic form of congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency was presumed the cause of virilization. As the glucocorticoid therapy did not normalize high levels of 17-OHP and androgens, and the DNA analysis did not demonstrate a mutation causing CAH, a laparotomy was performed. Near the right ovary a tumor was found and extirpated. Pathohistological studies determined it to be a rare steroid cell tumor, ‘not otherwise specified’. Within the next months the signs of virilization resolved and menarche occurred. Conclusions: Steroid cell tumor should be considered in differential diagnosis of virilization in childhood. Regarding the age of our patient and pathohistological findings of the tumor, her prognosis is favorable.
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- Ferriman D, Gallwey JD: Clinical assessment of body hair growth in women. J Clin Endocrinol Metab 1961;21:1440–1447.
- Hayes MC, Scully RE: Ovarian steroid cell tumors (not otherwise specified). A clinicopathological analysis of 63 cases. Am J Surg Pathol 1987;11:835–845.
- Harris AC, Wakely PE Jr, Kaplowitz PB, Lovinger RD: Steroid cell tumor of the ovary in a child. Arch Pathol Lab Med 1991;115:150–154.
- Azizlerli H, Tanakol R, Terzioğlu T, Alagöl F, Dizdaroglu F: Steroid cell tumor of the ovary as a rare cause of virilization. Mt Sinai J Med 1997;64:130–135.
- Bas F, Saka N, Darendeliler F, Tuzlali S, Ilhan R, Bundak R, Gunoz H: Bilateral ovarian steroid cell tumor in congenital adrenal hyperplasia. J Pediatr Endocrinol Metab 2000;13:663–667.
- Lin CJ, Jorge AA, Latronico AC, Marui S, Fragoso MC, Martin RM, Carvalho FM, Arnhold IJ, Mendonca BB: Origin of an ovarian steroid cell tumor causing isosexual pseudoprecocious puberty demonstrated by the expression of adrenal steroidogenic enzymes and adrenocorticotropin receptor. J Clin Endocrinol Metab 2000;85:1211–1214.
- Snyder D, LaFranchi S: Severe virilization in a girl with a steroid cell tumor of the ovary. J Pediatr Endocrinol Metab 1999;12:221–224.
- Van Ingen G, Schoemaker J, Baak JPA: A testosterone-producing tumour in the mesovarium. Pathol Res Pract 1991;187:362–370.