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Vol. 55, No. 5, 2001
Issue release date: 2001
Horm Res 2001;55:254–257

Extraovarian Steroid Cell Tumor ‘Not Otherwise Specified’ as a Rare Cause of Virilization in Twelve-Year-Old Girl

Dumić M. · Šimunić V. · Ilić-Forko J. · Cvitanović M. · Plavšić V. · Janjanin N. · Ille J.
aDepartment of Pediatrics, University Hospital Zagreb-Rebro; bDepartment of Gynecology and Obstetrics, University Hospital Zagreb and cEndocrinological Laboratory, University Hospital Zagreb-Rebro, Zagreb, Croatia

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Background: We present a 12-year-old girl with a 5-year history of progressive virilization. Results: Regarding elevated plasma levels of 17-hydroxyprogesterone (17-OHP) and androgens, normal ultrasound and CT scan of ovaries and adrenal glands, the nonclassic form of congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency was presumed the cause of virilization. As the glucocorticoid therapy did not normalize high levels of 17-OHP and androgens, and the DNA analysis did not demonstrate a mutation causing CAH, a laparotomy was performed. Near the right ovary a tumor was found and extirpated. Pathohistological studies determined it to be a rare steroid cell tumor, ‘not otherwise specified’. Within the next months the signs of virilization resolved and menarche occurred. Conclusions: Steroid cell tumor should be considered in differential diagnosis of virilization in childhood. Regarding the age of our patient and pathohistological findings of the tumor, her prognosis is favorable.

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    External Resources

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    External Resources

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