Intervirology 2001;44:215–218

Hepatitis C Virus and GBV-C/Hepatitis G Virus in Argentine Patients with Porphyria Cutanea Tarda

Oubiña J.R.a · Quarleri J.F.a · Sawicki M.A.b · Mathet V.L.a · Ruiz V.a · Schroder T.b · Méndez M.c · Parera V.c · Muramatsu H.c · Battle A.c · González Cappa S.M.a · Fainboim H.A.b
aDepartment of Microbiology, Faculty of Medicine, University of Buenos Aires, bCIPYP Buenos Aires, and cHepatology Unit, Muñiz Hospital, Buenos Aires, Argentina
email Corresponding Author

 goto top of outline Key Words

  • Hepatitis C virus
  • Porphyria cutanea tarda

 goto top of outline Abstract

To investigate hepatitis C virus (HCV) and GBV-C/hepatitis G virus (HGV) genotype prevalence among HCV-infected porphyria cutanea tarda (PCT) patients, 19 HCV-infected patients with associated PCT were studied. A control group of 53 age-matched HCV-infected patients without associated PCT was selected. Eighteen of the 19 serologically positive HCV-PCT patients showed HCV RNA in serum. Genotype 1b was the most prevalent among both HCV-PCT patients (72.2%; 13/18) and age-matched HCV controls (50.9%; 27/53). Such different genotypic prevalence failed to reach statistical significance (=χ2 with Yates’ correction, p = 0.19). The single HCV-PCT patient without detectable HCV RNA was also infected with genogroup 3 GBV-C/HGV. This GBV-C/HGV RNA prevalence (5.3%) among HCV-PCT patients is not statistically different from that observed among Argentine blood donors (5.5%; 11/200). To our knowledge, these results show for the first time the molecular epidemiology of both HCV and GBV-C/HGV associated to PCT in America.

Copyright © 2001 S. Karger AG, Basel

 goto top of outline References
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 goto top of outline Author Contacts

José Raúl Oubiña
Department of Microbiology, Faculty of Medicine, University of Buenos Aires
Paraguay 2155. Piso 11
1121 Buenos Aires (Argentina)
Tel. +54 11 4508 3689, Fax +54 11 4508 3705, E-Mail

 goto top of outline Article Information

Received: Received: March 14, 2000
Accepted after revision: November 27, 2000
Number of Print Pages : 4
Number of Figures : 0, Number of Tables : 1, Number of References : 12

 goto top of outline Publication Details

Intervirology (International Journal of Basic and Medical Virology)
Founded 1973 by J.L. Melnick; continued by F. Rapp (1986–1990); M.J. Buchmeier and C.R. Howard (1991–1993)

Vol. 44, No. 4, Year 2001 (Cover Date: July-August 2001)

Journal Editor: Rüdiger W. Braun, Stuttgart
ISSN: 0300–5526 (print), 1423–0100 (Online)

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