- Hepatitis C virus
- Porphyria cutanea tarda
To investigate hepatitis C virus (HCV) and GBV-C/hepatitis G virus (HGV) genotype prevalence among HCV-infected porphyria cutanea tarda (PCT) patients, 19 HCV-infected patients with associated PCT were studied. A control group of 53 age-matched HCV-infected patients without associated PCT was selected. Eighteen of the 19 serologically positive HCV-PCT patients showed HCV RNA in serum. Genotype 1b was the most prevalent among both HCV-PCT patients (72.2%; 13/18) and age-matched HCV controls (50.9%; 27/53). Such different genotypic prevalence failed to reach statistical significance (=χ2 with Yates’ correction, p = 0.19). The single HCV-PCT patient without detectable HCV RNA was also infected with genogroup 3 GBV-C/HGV. This GBV-C/HGV RNA prevalence (5.3%) among HCV-PCT patients is not statistically different from that observed among Argentine blood donors (5.5%; 11/200). To our knowledge, these results show for the first time the molecular epidemiology of both HCV and GBV-C/HGV associated to PCT in America.
Copyright © 2001 S. Karger AG, Basel
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José Raúl Oubiña
Department of Microbiology, Faculty of Medicine, University of Buenos Aires
Paraguay 2155. Piso 11
1121 Buenos Aires (Argentina)
Tel. +54 11 4508 3689, Fax +54 11 4508 3705, E-Mail firstname.lastname@example.org
Received: Received: March 14, 2000
Accepted after revision: November 27, 2000
Number of Print Pages : 4
Number of Figures : 0, Number of Tables : 1, Number of References : 12
Intervirology (International Journal of Basic and Medical Virology)
Founded 1973 by J.L. Melnick; continued by F. Rapp (1986–1990); M.J. Buchmeier and C.R. Howard (1991–1993)
Vol. 44, No. 4, Year 2001 (Cover Date: July-August 2001)
Journal Editor: Rüdiger W. Braun, Stuttgart
ISSN: 0300–5526 (print), 1423–0100 (Online)
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