Neuronal Substrates for Semantic Memory: A Positron Emission Tomography Study in Alzheimer’s DiseaseHirono N. · Mori E. · Ishii K. · Imamura T. · Tanimukai S. · Kazui H. · Hashimoto M. · Takatsuki Y. · Kitagaki H. · Sasaki M.
Divisions of aClinical Neurosciences and bNeuroimaging Research, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
We examined 57 patients with mild Alzheimer’s disease by using three kinds of verbal semantic memory tests (category fluency, confrontation naming and generation of verbal definition) and correlated each score with regional cerebral glucose metabolism determined by 18F-fluorodeoxyglucose and positron emission tomography. The scores of all three verbal semantic memory tests correlated significantly with regional cerebral glucose metabolism in the left inferior temporal gyrus, even after controlling for the effects of age, sex and educational attainment. In contrast, the scores of the word recall test did not correlate significantly with regional cerebral glucose metaboliosm in the left inferior temporal gyrus, neither before nor after controlling for these confounders. Our results suggested that the left inferior temporal lobe contributes to verbal semantic memory.
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