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Vol. 12, No. 2, 2001
Issue release date: March–April 2001
Section title: Original Research Article
Dement Geriatr Cogn Disord 2001;12:167–170
(DOI:10.1159/000051252)

Circulating Leptin Levels and Weight Loss in Alzheimer’s Disease Patients

Power D.A. · Noel J. · Collins R. · O’Neill D.
aDepartment of Clinical Geratology, Radcliffe Infirmary, Oxford, UK; bDepartment of Medicine for the Elderly, Mater Misericordiae Hospital, and cDepartment of Age-Related Health Care, Adeleaide, Meath and National Childrens Hospital, Tallaght, Dublin, Ireland

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Published online: 2/9/2001

Number of Print Pages: 4
Number of Figures: 2
Number of Tables: 2

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

Weight loss is common in Alzheimer’s disease (AD) and is predictive of mortality. Leptin, an adipocyte-derived peptide hormone is implicated in the regulation of satiety and energy expenditure. It acts on the hypothalamus to suppress appetite and increase energy expenditure. We undertook this study to determine if inappropriately elevated leptin levels play a role in AD-associated weight loss. Serum leptin levels of 8 patients in each of the following groups were determined: (1) AD, body mass index (BMI) >25; (2) AD, BMI <20; (3) non-Alzheimer’s (vascular) dementia (VaD), BMI >25, and (4) VaD, BMI <20. Mean serum leptin levels were significantly lower in below-appropriate-weight patients (both AD and VaD) than in appropriate-weight controls. Below-appropriate-weight AD patients had a significantly lower mean serum leptin concentration than appropriate-weight VaD controls. Weight loss is a feature of AD. Inappropriately elevated leptin levels do not appear to be implicated. Indeed, we have shown that the afferent limb of the leptin feedback loop is intact in below-appropriate-weight AD patients and suggest hypothalamic dysfunction may underlie this feature.


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Published online: 2/9/2001

Number of Print Pages: 4
Number of Figures: 2
Number of Tables: 2

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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References

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    External Resources

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