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Vol. 63, Suppl. 1, 2001
Issue release date: 2001
Digestion 2001;63(suppl 1):93–96

Helicobacter pylori Infection Increases Mucosal Permeability of the Stomach and Intestine

Fukuda Y. · Bamba H. · Okui M. · Tamura K. · Tanida N. · Satomi M. · Shimoyama T. · Nishigami T.
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It is important to study the effect of Helicobacter pylori infection on the permeability of the intestine. Permeability was evaluated by oral sucrose tolerance test using sucrose 25 g in 200 ml of water. Existence of H. pylori itself was associated with increased permeability of sucrose. Also, the permeability of sucrose increased as polymorphonuclear and lymphocyte infiltration increased. The increase of mucosal permeability suggests that antigens like protein penetrate into the body and result in systemic reactions. Thus, it is important to study the implication of increased permeability in relation not only to gastric diseases but also certain systemic diseases.

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