To view the fulltext, please log in
To view the pdf, please log in
- FullText & PDF
- Unlimited re-access via MyKarger (new!)
- Unrestricted printing, no saving restrictions for personal use
- Reduced rates with a PPV account
- Rent for 48h to view
- Buy Cloud Access for unlimited viewing via different devices
- Synchronizing in the ReadCube Cloud
- Printing and saving restriction apply
Rental: USD 8.50
Cloud: USD 20.00
- Automatic perpetual access to all articles of the subscribed year(s)
- Unlimited re-access via Subscriber Login or MyKarger
- Unrestricted printing, no saving restrictions for personal use
Article / Publication Details
Recent interest has focused on the use of hormone therapy in prostate cancer for both the management of patients with non-metastatic disease and as a neoadjuvant or adjuvant to curative therapies. This has resulted in patients with fewer symptoms being treated for longer periods of time. Endocrine treatments for prostate cancer, such as castration, combined androgen blockade and non-steroidal antiandrogen monotherapy, have shown similar results in terms of time to progression and survival. The main difference between these treatments is their impact on patients’ quality of life. Instruments for measuring health-related quality of life should assess both overall and disease-specific quality of life. Data from two large studies of bicalutamide monotherapy show that this non-steroidal antiandrogen is associated with significant health-related quality of life advantages in the treatment of patients with locally advanced (M0) disease compared with castration, suggesting that this treatment may benefit patients with early disease. Bicalutamide was favoured in 8 out of 9 evaluable quality of life dimensions, and this was statistically significant for sexual interest and physical capacity. Endocrine treatments with minimal adverse effects on quality of life will be increasingly favoured for patients with non-metastatic disease who are being treated for longer periods of time.
Article / Publication Details
Copyright / Drug Dosage
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
- Tyrrell CJ: Controversies in the management of advanced prostate cancer. Br J Cancer 1999;79:146–155.
- Kaisary AV, Tyrrell CJ, Peeling WB, Griffiths K: Comparison of LHRH analogue (Zoladex) with orchiectomy in patients with metastatic prostatic carcinoma. Br J Urol 1991;67:502–508.
- Vogelzang NJ, Chodak GW, Soloway MS, Block NL, Schellhammer PF, Smith JA Jr, Caplan RJ, Kennealey GT: Goserelin versus orchiectomy in the treatment of advanced prostate cancer: Final results of a randomized trial. Urology 1995;46:220–226.
- Prostate Cancer Trialists’ Collaborative Group: Maximum androgen blockade in advanced prostate cancer: An overview of 22 randomised trials with 3,283 deaths in 5,710 patients. Lancet 1995;346:265–269.
- Eisenberger MA, Blumenstein BA, Crawford ED, Miller G, McLeod DG, Loehrer PJ, Wilding G, Sears K, Culkin DJ, Thompson IM Jr, Bueschen AJ, Lowe BA: Bilateral orchiectomy with or without flutamide for metastatic prostate cancer. N Engl J Med 1998;339:1036–1042.
- Sarosdy MF, Schellhammer PF, Sharifi R, Block NL, Soloway MS, Venner PM, Patterson AL, Vogelzang NJ, Chodak GW, Klein EA, Schellenger JJ, Kolvenbag GJ: Comparison of goserelin and leuprolide in combined androgen blockade therapy. Urology 1998;52:82–88.
- Iversen P, Tyrrell CJ, Kaisary AV, Anderson JB, Baert L, Tammela T, Chamberlain M, Carroll K, Gotting-Smith K, Blackledge GRP: ‘Casodex’ (bicalutamide) 150 mg monotherapy compared with castration in patients with previously untreated nonmetastatic prostate cancer: Results from two multicenter randomized trials at a median follow-up of 4 years. Urology 1998;51:389–396.
- Barradell LB, Faulds D: Cyproterone. A review of its pharmacology and therapeutic efficacy in prostate cancer. Drugs Aging 1994;5:59–80.
- McLeod DG: Tolerability of non-steroidal antiandrogens in the treatment of advanced prostate cancer. Oncologist 1997;2:18–27.
- Di Silverio F, Serio M, D’Eramo G: Zoladex vs Zoladex plus cyproterone acetate in the treatment of advanced prostatic cancer: A multicentre Italian study. Eur Urol 1990;18:54–61.
- Schröder FH, Whelan P, Kurth KH, de Pauw M and the EORTC GU Group: Antiandrogens as monotherapy for metastatic prostate cancer: A preliminary report on EORTC protocol 30892; in Schröder FH (ed): Recent Advances in Prostate Cancer and BPH. Proceedings of the IV Congress on Progress and Controversies in Oncological Urology (PACIOU IV). London, Parthenon, 1997, pp 141–146.
- Boccon-Gibod L: Nonsteroidal antiandrogen monotherapy for metastatic cancer of the prostate. Eur Urol 1994;24:77–80.
- Boccon-Gibod L, Fournier G, Bottet P, Marechal JM, Guiter J, Rischman P, Hubert J, Soret JY, Mangin P, Mallo C, Esctein Fraysse C: Flutamide versus orchidectomy in patients with metastatic prostate carcinoma. Eur Urol 1997;32:391–395.
- Brogden RN, Chrisp P: Flutamide: A review of its pharmacokinetic and pharmacodynamic properties and therapeutic use in prostate cancer. Drugs Aging 1991;1:104–115.
- Chang A, Yeap B, Davis T, Blum R, Hahn R, Khanna O, Fisher H, Rosenthal J, Witte R, Schinella R, Trump D: Double-blind randomised study of primary hormonal treatment of stage D2 prostate carcinoma: Flutamide vs diethylstilbestrol. J Clin Oncol 1996;14:2250–2253.
- Tyrrell CJ, Kaisary AV, Iversen P, Anderson JB, Baert L, Tammela T, Chamberlain M, Webster A, Blackledge G: A randomised comparison of ‘Casodex’ (bicalutamide) 150 mg monotherapy versus castration in the treatment of metastatic and locally advanced prostate cancer. Eur Urol 1998;33:447–456.
- Samdal F, Kleppe G, Amland PF, Abyholm F: Surgical treatment of gynaecomastia. Five years’ experience with liposuction. Scand J Reconstr Surg Hand Surg 1994;28:123–130.
- Braunstein GD, Glassman HA: Gynecomastia. Curr Ther Endocrinol Metab 1997;6:401–404.
- Oosterlinck W, Casselman J , Mattelaer J, Van Velthoven R, Kurjatkin O, Schulman C: Tolerability and safety of flutamide in monotherapy with orchiectomy or with LHRHa in advanced prostate cancer patients. Eur Urol 1996;30:458–463.
- Soloway MS, Schellhammer P, Sharifi R, Venner P, Patterson AL, Sarosdy M, Vogelzang N, Jones J, Kolvenbag G: A controlled trial of ‘Casodex’ (bicalutamide) versus flutamide, each in combination with luteinising hormone-releasing hormone analogue therapy in patients with advanced prostate cancer. Eur Urol 1996;29:105–109.
- Goa KL, Spencer CM: Bicalutamide in advanced prostate cancer: A review. Drugs Aging 1998;12:401–422.
- Schröder FH: Antiandrogens as monotherapy for prostate cancer. Eur Urol 1998;34:12–17.
- Wysowski DK, Fourcroy JL: Flutamide hepatotoxicity. J Urol 1996;155:209–212.
- World Health Organization: World Health Organization Quality of Life Assessment (WHOQOL): Development and general psychometric properties. Soc Sci Med 1998;46:1569–1585.
- Cleary PD, Morrissey G, Oster G: Health-related quality of life in patients with advanced prostate cancer: A multinational perspective. Qual Life Res 1995;4:207–220.
- Helgason AR, Adolfsson J, Dickman P, Fredrikson M, Arver S, Steineck G: Waning sexual function – the most important disease-specific distress for patients with prostate cancer. Br J Cancer 1996;73:1417–1421.
- Singer PA, Tasch ES, Stocking C, Rubin S, Siegler M, Weichselbaum R: Sex or survival: Trade-offs between quality and quantity of life. J Clin Oncol 1991;9:328–334.
- Mazur DJ, Hickam DH: Patient preferences: Survival versus quality of life considerations. J Gen Intern Med 1993;8:374–377.
- Boccardo F, Rubagotti A, Barichello M, Battaglia M, Carmignani G, Comen G, Conn G, Cruciani G, Dammino S, Delliponti U, Ditonno P, Ferrans V, Lilliu S, Montefiore F, Portoghese F, Spano G for the Italian Prostate Cancer Project: Bicalutamide monotherapy versus flutamide plus goserelin in prostate cancer patients. Results of an Italian Prostate Cancer Project (PONCAP) Study. J Clin Oncol 1999;17:2027–2038.
- van Basten JP, van Driel MF, Jonker Pool G, Sleijfer DT, Schraffordtkoops H, van de Wiel HB, Hoekstra HJ: Sexual functioning in testosterone-supplemented patients treated for bilateral testicular cancer. Br J Urol 1997;79:461–467.
- Leifke E, Korner HC, Link TM, Behre HM, Peters PE, Nieschlag E: Effects of testosterone replacement therapy on cortical and trabecular bone mineral density, vertebral body area and paraspinal muscle area in hypogonadal men. Eur J Endocrinol 1998;138:51–58.
- Sih R, Morley JE, Kaiser FE, Perry HM, Patrick P, Ross C: Testosterone replacement in older hypogonadal men: A 12-month randomised controlled trial. J Clin Endocrinol Metab 1997;82:1661–1667.