Monocyte/granulocyte progenitor cells of the bone marrow are a major site of human cytomegalovirus (HCMV) latency. The mechanisms of establishment and maintenance of HCMV latency are still unknown. Reactivation of the latent virus in bone-marrow-derived progenitor cells has been demonstrated in vitro and suggested to occur also in vivo. Clinical studies have shown that reactivation is a rather frequent event not only in immunosuppressed but also in nonimmunosuppressed patients and in healthy blood donors. At least three independent mechanisms of virus reactivation are discussed: systemic inflammation connected with strong tumor necrosis factor alpha release; application of cAMP-elevating drugs, and highly stressful events associated with increased plasma catecholamine levels.
© 2000 S. Karger AG, Basel
- Human cytomegalovirus
- Virus reactivation
- Monocyte/granulocyte progenitor cells
- Systemic inflammation
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PD Dr. Susanna Prösch
Institut für Virologie, Universitätsklinikum Charité
Campus Charité-Mitte, Humboldt-Universität
Schumannstrasse 20/21, D–10098 Berlin (Germany)
Tel. +49 30 2802 3117, Fax +49 30 2802 2180, E-Mail firstname.lastname@example.org
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Intervirology (International Journal of Basic and Medical Virology)
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