Vol. 43, No. 4-6, 2000
Issue release date: July–December 2000 (February 2001)
Intervirology 2000;43:302–311
(DOI:10.1159/000053998)
Paper
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DNA-Based Immunization against Lyssaviruses

Perrin P. · Jacob Y. · Tordo N.
Laboratoire des Lyssavirus, Institut Pasteur, Paris, France
email Corresponding Author


 goto top of outline Key Words

  • Vaccine
  • DNA
  • Rabies
  • Lyssaviruses
  • Glycoprotein
  • Chimeras
  • Responses, immunological

 goto top of outline Abstract

Rabies is a fatal encephalomyelitis. Most cases occur in developing countries and are transmitted by dogs. Because of their high cost, cell culture vaccines have not totally replaced the unsafe brain-derived vaccines which are still used in many developing countries. Moreover, there will be a need for vaccines against rabies-related viruses against which classical vaccines are not always effective. DNA vaccines would, therefore, be a valuable alternative for the production of cheaper rabies vaccines against a larger spectrum of viruses. In this review we report published data on DNA-based immunization with sequences encoding rabies and rabies-related virus antigens.

Copyright © 2001 S. Karger AG, Basel


 goto top of outline References
  1. Dreesen D: A global review of rabies vaccines for human use. Vaccine 1997;15:S2–S6.
  2. Meslin FX, Fishbein D, Matter H: Rationale and prospects for rabies elimination in developping countries; in Rupprecht C (ed): Lyssaviruses. Berlin, Springer, 1994, p 26.
  3. Pastoret PP, Brochier B, Aguilar-Setien A, Blancou J: Vaccination against rabies; in Pastoret P-P, Blancou J, Vannier P, Verschueren C (eds): Veterinary Vaccinology. Amsterdam, Elsevier, 1997, p 616.
  4. Bourhy H, Kissi B, Tordo N: Molecular diversity of the Lyssavirus genus. Virology 1993;194:70–81.
  5. Gould A, Hyatt A, Lunt R, Kattenbelt J, Hengstberger S, Blacksell S: Characterization of a novel lyssavirus isolated from Pteropid bat in Australia. Virus Res 1998;54:165–187.

    External Resources

  6. Wolff J, Malone R, Williams P, Chong W, Acsadi G, Jani A, Felgner P: Direct gene transfer into mouse muscle cells in vivo. Science 1990;247:1465–1468.
  7. Tang D, DeVit M, Johnston S: Genetic immunization is a simple method for eliciting an immune response. Nature 1992;356:152–154.
  8. Donnelly J, Ulmer J, Shiver J, Liu M: DNA vaccines. Annu Rev Immunol 1997;15:617–648.
  9. Kowalczyk D, Ertl H: Immune responses to DNA vaccines. Cell Mol Life Sci 1999;55:751–770.

    External Resources

  10. Wiktor T, Gyorgy E, Schlumberger D, Sokol F, Koprowski H: Antigenic properties of rabies virus components. J Immunol 1973;110:269–276.

    External Resources

  11. Atanasiu P, Tsiang H, Perrin P, Favre S, Sisman J: Extraction d’un antigène soluble (glycoprotéine) par le Triton × 100 à partir d’un vaccin antirabique de culture tissulaire de premier explant. Résultats d’immunisation et pouvoir protecteur. Ann Microbiol (Paris) 1974;125B:539–557.
  12. Xiang Z, Spitalnik S, Tran M, Wunner W, Cheng J, Ertl H: Vaccination with a plasmid vector carrying the rabies virus glycoprotein gene induces protective immunity against rabies virus. Virology 1994;199:132–140.
  13. Ertl H, Verma P, Xiang Z: Plasmid vectors as anti-viral vaccines. DNA vaccines: A new era in vaccinology. Ann NY Acad Sci 1995;772:77–87.
  14. Xiang Z, Spitalnik S, Cheng J, Erikson J, Wojczyk B, Ertl H: Immune responses to nucleic acid vaccines to rabies virus. Virology 1995;209:569–579.
  15. Xiang Z, He Z, Wang Y, Ertl H: The effect of interferon-γ on genetic immunisation. Vaccine 1997;15:896–898.

    External Resources

  16. Xiang Z, Ertl H: Manipulation of the immune response to a plasmid-encoded viral antigen by coinoculation with plasmids expressing cytokines. Immunity 1995;2:129–135.

    External Resources

  17. Ray N, Ewalt L, Lodmell D: Nanogram quantities of plasmid DNA encoding the rabies virus glycoprotein protect mice against lethal rabies virus infection. Vaccine 1997;15:892–895.

    External Resources

  18. Lodmell D, Ray N, Ewalt L: Gene gun particle-mediated vaccination with plasmid DNA confers protective immunity against rabies virus infection. Vaccine 1998;16:115–118.

    External Resources

  19. Bahloul C, Jacob Y, Tordo N, Perrin P: DNA-based immunization for exploring the enlargement of immunological cross-reactivity against the lyssaviruses. Vaccine 1998;16:417–425.

    External Resources

  20. Jallet C, Jacob Y, Bahloul C, Drings A, Desmézières E, Tordo N, Perrin P: Chimeric lyssavirus glycoproteins with increased immunological potential. J Virol 1999;73:225–233.

    External Resources

  21. Biswas S, Ashok M, Reddy G, Srinivasan V, Rangarajan P: Evaluation of the protective efficacy of a rabies DNA vaccine in mice using an intracerebral challenge model. Curr Sci 1999;76:1012–1016.
  22. Osorio J, Tomlinson G, Frank R, Haanes E, Rushlow K, Haynes J, Stinchcomb D: Immunization of dogs and cats with a DNA vaccine against rabies virus. Vaccine 1999;17:1109–1116.

    External Resources

  23. Anilionis A, Wunner W, Curtis P: Structure of the glycoprotein gene in rabies virus. Nature 1981;294:275–278.
  24. Delagneau JF, Perrin P, Atanasiu P: Structure of the rabies virus: Spatial relationships of the proteins G, M1, M2 and N. Ann Virol (Paris) 1981;132E:473–493.
  25. Gaudin Y, Ruigrok R, Tuffereau C, Knossow M, Flamand A: Rabies glycoprotein is a trimer. Virology 1992;187:627–632.

    External Resources

  26. Benmansour A, Leblois H, Coulon P, Tuffereau C, Gaudin Y, Flamand A, Lafay F: Antigenicity of rabies virus glycoprotein. J Virol 1991;65:4198–4203.

    External Resources

  27. Desmézières E, Jacob Y, Saron M-F, Delpeyroux F, Tordo N, Perrin P: Lyssavirus glycoproteins expressing immunologically potent foreign B cell and cytotoxic T lymphocyte epitopes as prototypes for multivalent vaccines. J Gen Virol 1999;80:2343–2351.
  28. Ertl H, Xiang Z: Genetic immunization. Viral Immunol 1996;9:1–9.

    External Resources

  29. Drings A, Jallet C, Chambert B, Tordo N, Perrin P: Is there an advantage to including the nucleoprotein in a rabies glycoprotein subunit vaccine? Vaccine 1999;17:1549–1457.

    External Resources

  30. Lodmell D, Ray N, Parnell M, Ewalt L, Hanlon C, Shaddock J, Sanderlin D, Rupprecht C: DNA immunization protect nonhuman primates against rabies virus. Nat Med 1998;4:949–952.

    External Resources

  31. Perrin P, Jacob Y, Aguilar-Setien A, Loza-Rubio E, Jallet C, Desmézières E, Aubert M, Cliquet F, Tordo N: Immunization of dogs with a DNA vaccine induces protection against rabies virus. Vaccine 1999;18:479–486.
  32. Ertl H, Xiang Z: DNA vaccines to rabies virus: Effects of cytokines on the immune response; in Vaccine 96: Molecular Approaches to the Control of Infectious Diseases. New York, Cold Spring Harbor Laboratory Press, 1996, pp 83–86.
  33. Xiang Z, Kwowles B, McCarrick J, Ertl H: Immune effector mechanisms required for protection to rabies virus. Virology 1995;214:398–404.
  34. Wang Y, Xiang Z, Pasquini S, Ertl H: Immune response to neonatal genetic immunization. Virology 1997;228:278–284.

    External Resources

  35. Wang Y, Xiang Z, Pasquini S, Ertl H: Effect of passive immunization or maternally transferred immunity on the antibody response to a genetic vaccine to rabies virus. J Virol 1998;72:1790–1796.

    External Resources


 goto top of outline Author Contacts

Dr. Pierre Perrin
Laboratoire des Lyssavirus, Institut Pasteur
25, rue du Dr. Roux
F–75724 Paris (France)
Tel. +33 1 45 68 87 56, Fax +33 1 40 61 32 56, E-Mail pperrin@pasteur.fr


 goto top of outline Article Information

Number of Print Pages : 10
Number of Figures : 4, Number of Tables : 1, Number of References : 35


 goto top of outline Publication Details

Intervirology (International Journal of Basic and Medical Virology)
Founded 1973 by J.L. Melnick; continued by F. Rapp (1986–1990); M.J. Buchmeier and C.R. Howard (1991–1993)

Vol. 43, No. 4-6, Year 2000 (Cover Date: July-December 2000 (Released February 2001))

Journal Editor: Rüdiger W. Braun, Stuttgart
ISSN: 0300–5526 (print), 1423–0100 (Online)

For additional information: http://www.karger.com/journals/int


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