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Table of Contents
Vol. 1, No. 4, 2001
Issue release date: 2001
Pancreatology 2001;1:356–362

From Acinar Cell Damage to Systemic Inflammatory Response: Current Concepts in Pancreatitis

Weber C.K. · Adler G.
Department of Medicine I, University of Ulm, Germany

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Acute pancreatitis represents a local inflammatory disorder with severe systemic consequences. Significant progress in understanding the pathophysiology of acute pancreatitis has been achieved in recent years. However, there is no clear concept about initialization and propagation of the disease both in experimental models and in humans. Furthermore, reliable strategies to evaluate prognosis and perform therapy are still missing. The review focuses on mechanisms originating from acinar cells leading to a systemic inflammatory response in experimental pancreatitis.

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