Journal Mobile Options
Table of Contents
Vol. 34, No. 3, 2001
Issue release date: March 2001
Pediatr Neurosurg 2001;34:124–130
(DOI:10.1159/000056007)

Pathogenesis of Lumbosacral Lipoma: A Test of the ‘Premature Dysjunction’ Theory

Li Y.C. · Shin S.-H. · Cho B.-K. · Lee M.-S. · Lee Y.-J. · Hong S.-K. · Wang K.-C.
To view the fulltext, log in and/or choose pay-per-view option

Individual Users: Register with Karger Login Information

Please create your User ID & Password





Contact Information











I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Abstract

Premature separation of the neuroectoderm from the ipsilateral surface ectoderm allowing mesenchymal tissue to invade into the central canal, or ‘premature dysjunction’ theory, was proposed for the pathogenesis of dorsal type lumbosacral lipoma. To test this theory, the unilateral neural fold was incised using Hamburger and Hamilton stage 12 or 13 chick embryos. Among 35 embryos evaluated, 15 showed abnormal findings, and of these one showed findings which suggested lumbosacral lipoma: a back lump, blending of the neuroepithelium and mesenchyme through indistinct basement membrane and vertebral body abnormalities. The other 14 embryos showed abnormalities including blunt tails, open neural tube defects, incomplete closure of the dorsal neuroepithelium with intact skin, skin dimples, disorganized gray matter, scoliosis, ectopic neuroepithelium and an accessory spinal cord. The results revealed that the incision of the unilateral neural fold in the early chick embryo may produce a lesion suggestive of lumbosacral lipoma, a finding which supports the premature dysjunction theory. This method needs further refinement to overcome technical difficulties, high mortality, and a low yield before being adopted as an experimental model for lumbosacral lipoma.



Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

References

  1. Bruce DA, Schut L: Spinal lipomas in infancy and childhood. Childs Brain 1979;5:192–203.

    External Resources

  2. Schut L, Bruce DA, Sutton LN: The management of the child with a lipomyelomeningocele. Clin Neurosurg 1983;30:446–476.
  3. Kanev PM, Lemire RJ, Loeser JD, Berger M: Management and long-term follow-up review of children with lipomyelomeningocele, 1952–1987. J Neurosurg 1990;73:48–52.
  4. Naidich TP, McLone DG, Mutluer S: A new understanding of dorsal dysraphism with lipoma (lipomyeloschisis): Radiologic evaluation and surgical correction. AJR Am J Roentgenol 1983;140:1065–1078.

    External Resources

  5. McLone DG, Naidich TP: Spinal dysraphism: Experimental and clinical; in Holtzman RN, Stein BM (eds): The Tethered Spinal Cord. New York, Thieme-Stratton, 1985, pp 14–28.
  6. Walsh JW, Markesbery WR: Histological features of congenital lipoma of the lower spinal cord. J Neurosurg 1980;52:564–569.
  7. French BN: Abnormal development of the central nervous system; in McLaurin RL, Venes JL, Schut L, Epstein F (eds): Pediatric Neurosurgery: Surgery of the Developing Nervous System, ed 2. Philadelphia, Saunders, 1989, pp 9–34.
  8. Hamburger V, Hamilton HL: A series of normal stages in the development of the chick embryo. J Morphol 1951;88:49–92.
  9. Inagaki T, Wang KC, Higbee RG, McLone DG, Knepper PA: Concanavalin-A-induced open neural tube defects in chick embryos. Neurol Med Chir (Tokyo) 1996;36:691–697.

    External Resources

  10. Pierre-Kahn A, Zerah M, Renier D, Cinalli G, Sainte-Rose C, Lellouch Tubiana A, Brunelle F, Le Merrer M, Giudicelli Y, Pichon J, Kleinknecht B, Nataf F: Congenital lumbosacral lipomas. Childs Nerv Syst 1997;13:298–334.
  11. Chapman PH: Congenital intraspinal lipomas: Anatomic considerations and surgical treatment. Childs Brain 1982;9:37–47.

    External Resources

  12. Griffith CM, Sanders EJ: Effects of extracellular matrix components on the differentiation of chick embryo tail bud mesenchyme in culture. Differentiation 1991;47:61–68.
  13. Griffith CM, Wiley MJ, Sanders EJ: The vertebrate tail bud: Three germ layers from one tissue. Anat Embryol (Berl) 1992;185:101–113.
  14. Hoornbeek FK, Adams MJ: Modification toward dominance of a recessive lethal in the mouse. J Hered 1975;66:124–126.

    External Resources

  15. Embury S, Seller MJ, Adinolfi M, Polani PE: Neural tube defects in curly-tail mice. I. Incidence, expression and similarity to the human condition. Proc R Soc Lond B Biol Sci 1979;206:85–94.
  16. Alton AK, Silver LM, Artzt K, Bennett D: Molecular analysis of the genetic relationship of trans interacting factors at the T/t complex. Nature 1980;288:368–370.

    External Resources

  17. Paterson HF: In vivo and in vitro studies on the early embryonic lethal tail-short (Ts) in the mouse. J Exp Zool 1980;211:247–256.

    External Resources

  18. Barra J: An X-linked recessive mutation producing cleft palate, crooked tail, and polydactyly in mice. J Hered 1990;81:388–392.
  19. Rossi JM, Chen H, Tilghman SM: Genetic map of the fused locus on mouse chromosome 17. Genomics 1994;23:178–184.
  20. Tsukahara K, Hirasawa T, Makino S: Tss (Tail-short Shionogi), a new short tail mutation found in the BALB/cMs strain, maps quite closely to the Tail-short (Ts) locus on mouse chromosome 11. Exp Anim 2000;49:131–135.
  21. Costanzo R, Watterson RL, Schoenwolf GC: Evidence that secondary neurulation occurs autonomously in the chick embryo. J Exp Zool 1982 ; 219:233–240.
  22. Reigel DH, McLone DG: Tethered spinal cord; in Cheek WR, Marlin AE, McLone DG, Reigel DH, Walker ML (eds): Pediatric Neurosurgery: Surgery of the Developing Nervous System, ed 3. Philadelphia, Saunders, 1994, pp 77–95.


Pay-per-View Options
Direct payment This item at the regular price: USD 38.00
Payment from account With a Karger Pay-per-View account (down payment USD 150) you profit from a special rate for this and other single items.
This item at the discounted price: USD 26.50