Journal Mobile Options
Table of Contents
Vol. 35, No. 1, 2002
Issue release date: January–February 2002
Section title: Original Paper
Psychopathology 2002;35:8–16
(DOI:10.1159/000056210)

An Exploratory Study on Obsessive-Compulsive Disorder with and without a Familial Component: Are There Any Phenomenological Differences?

Albert U. · Maina G. · Ravizza L. · Bogetto F.
Department of Neuroscience, Anxiety and Mood Disorders Unit, University of Turin, Turin, Italy

Do you have an account?

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger (new!)
  • Unrestricted printing, no saving restrictions for personal use
  • Reduced rates with a PPV account
read more

Direct: USD 38.00
Account: USD 26.50

Select

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restriction apply

Rental: USD 8.50
Cloud: USD 20.00

Select

Subscribe

  • Automatic perpetual access to all articles of the subscribed year(s)
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 4/29/2002

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 7

ISSN: 0254-4962 (Print)
eISSN: 1423-033X (Online)

For additional information: http://www.karger.com/PSP

Abstract

Familial studies on obsessive-compulsive disorders (OCD) have suggested that OCD is a heterogeneous condition, with some cases being familial and others being isolated cases in their families. Nevertheless, no studies evaluated whether there are clinical differences between OCD cases with and without a familial component. The current report presents data on the prevalence of OCD in first-degree relatives of OCD probands and compares phenomenological characteristics of familial and non-familial OCD types. The family study and the family history methods were used to estimate the prevalence of OCD in first-degree relatives of 74 OCD probands. A statistical comparison between OCD probands with and without familial loading was performed using Pearson’s χ2 test, Fisher’s exact test, or Student’s t test when appropriate. The rate of OCD was 3.5% in directly interviewed first-degree relatives. Eleven percent of the probands had at least one family member with OCD. There were no differences between the two types of OCD (familial vs. non-familial) except for life events prior to the onset of OCD, which were more common and more severe in non-familial OCD subtypes. In conclusion, our results (1) confirm that there is a familial component in the expression of some forms of OCD and (2) indicate that familial OCD patients are not characterized by peculiar clinical features, but appear to have a lower threshold for precipitating events.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 4/29/2002

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 7

ISSN: 0254-4962 (Print)
eISSN: 1423-033X (Online)

For additional information: http://www.karger.com/PSP


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

References

  1. Lewis A: Problems of obsessional illness. Proc R Soc Med 1935;29:325–336.
  2. Brown FW: Heredity in the psychoneuroses. Proc R Soc Med 1942;35:785–790.
  3. Rudin E: Ein Beitrag zur Frage der Zwangskrankheit. Arch Psychiatr Nervenkr 1953;191:14–15.
  4. Kringlen E: Obsessional neurotics: A long-term follow-up. Br J Psychiatry 1965;111:709–722.
  5. Lo WH: A follow-up study of obsessional neurotics in Hong Kong Chinese. Br J Psychiatry 1967;113:823–832.

    External Resources

  6. Rosenberg CM: Familial aspects of obsessional neurosis. Br J Psychiatry 1967;113:405–413.
  7. Insel T, Hoover C, Murphy DL: Parents of patients with obsessive-compulsive disorder. Psychol Med 1983;13:807–811.

    External Resources

  8. Rasmussen SA, Tsuang MT: Clinical characteristics and family history in DSM-III obsessive-compulsive disorder. Am J Psychiatry 1986;143:317–322.

    External Resources

  9. McKeon P, Murray R: Familial aspects of obsessive compulsive neurosis. Br J Psychiatry 1987;151:528–534.

    External Resources

  10. Lenane MC, Swedo SE, Leonard H, Pauls DL, Sceery W, Rapoport JL: Psychiatric disorders in first-degree relatives of children and adolescents with obsessive-compulsive disorders. J Am Acad Child Adolesc Psychiatry 1990;29:407–412.
  11. Bellodi L, Sciuto G, Diaferia G, Ronchi P, Smeraldi E: Psychiatric disorders in the families of patients with obsessive-compulsive disorder. Psychiat Res 1992;42:111–120.
  12. Black DW, Noyes R Jr, Goldstein RB, Blum N: A family study of obsessive-compulsive disorder. Arch Gen Psychiatry 1992;49:362–368.
  13. Leonard HL, Lenane MC, Swedo SE, Rettew DC, Gershon ES, Rapoport JL: Tics and Tourette’s disorder: A 2- to 7-year follow-up of 54 obsessive-compulsive children. Am J Psychiatry 1992;149:1244–1251.
  14. Nicolini H, Weissbecker K, Mejia JM, Sanchez de Carmona M: Family study of obsessive-compulsive disorder in a Mexican population. Arch Med Research 1993;24:193–198.
  15. Riddle MA, Scahill L, King R, Hardin MD, Towbin KE, Ort SI, Leckman JF, Cohen DJ: Obsessive-compulsive disorder in children and adolescents: Phenomenology and family history. J Am Acad Child Adolesc Psychiatry 1990;29:766–772.
  16. Pauls DL, Alsobrook JP 2nd, Goodman W, Rasmussen S, Leckman JF: A family study of obsessive-compulsive disorder. Am J Psychiatry 1995;152:76–84.
  17. Alsobrook JP, Leckman JF, Goodman WK, Rasmussen SA, Pauls DL: Segregation analysis of obsessive-compulsive disorder using symptom-based factor scores. Am J Med Genet 1999;88:669–675.
  18. Ronchi P, Abbruzzese M, Erzegovesi S, Diaferia G, Sciuto G, Bellodi L: The epidemiology of obsessive-compulsive disorder in an Italian population. Eur Psychiatry 1992;7:53–59.
  19. Lensi P, Cassano GB, Correddu G, Ravagli S, Kunovac JL, Akiskal HS: Obsessive-compulsive disorder. Familial-developmental history, symptomatology, comorbidity and course with special reference to gender-related differences. Br J Psychiatry 1996;169:101–107.
  20. Ravizza L, Maina G, Bogetto F: Episodic and chronic obsessive-compulsive disorder. Depress Anxiety 1997;6:154–158.
  21. Nestadt G, Samuels J, Riddle M, Bienvenu OJ 3rd, Liang KY, LaBuda M, Walkup J, Grados M, Hoehn-Saric R: A family study of obsessive-compulsive disorder. Arch Gen Psychiatry 2000;57:358–363.
  22. Spitzer RL, Williams JBW, Gibbon M, First MB: User’s Guide for the Structured Clinical Interview for DSM III-R (SCID). Washington, American Psychiatric Press, 1990.
  23. Paykel ES, Prusoff BA, Uhlenhuth EH: Scaling of life event. Arch Gen Psychiatry 1971;25:340–347.
  24. Andreasen NC, Endicott J, Spitzer RL, Winokur G: The family history method using diagnostic criteria. Reliability and validity. Arch Gen Psychiatry 1977;34:1229–1235.
  25. Sobin C, Blundell ML, Karayiorgou M: Phenotypic differences in early- and late-onset obsessive-compulsive disorder. Compr Psychiatry 2000;41:373–379.