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Vol. 92, No. 3-4, 2001
Issue release date: 2001
Section title: Gene Mapping, Cloning and Sequencing
Cytogenet Cell Genet 92:204–208 (2001)
(DOI:10.1159/000056903)

An ATP-binding cassette gene (ABCG5) from the ABCG (White) gene subfamily maps to human chromosome 2p21 in the region of the Sitosterolemia locus

Shulenin S. · Schriml L.M. · Remaley A.T. · Fojo S. · Brewer B. · Allikmets R. · Dean M.
aLaboratory of Genomic Diversity, NCI-Frederick, Frederick MD; bNational Heart, Lung and Blood Institute, Bethesda MD; cDepartments of Ophthalmology and Pathology, Columbia University, New York NY (USA)

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Article / Publication Details

First-Page Preview
Abstract of Gene Mapping, Cloning and Sequencing

Published online: 6/28/2001

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR

Abstract

We characterized a new human ATP-binding cassette (ABC) transporter gene that is highly expressed in the liver. The gene, ABCG5, contains 13 exons and encodes a 651 amino acid protein. The predicted protein is closely related to the Drosophila white gene and a human gene, ABCG1, which is induced by cholesterol. This subfamily of genes all have a single ATP-binding domain at the N-terminus and a single C-terminal set of transmembrane segments. ABCG5 maps to human chromosome 2p21, between the markers D2S117 and D2S119. The abundant expression of this gene in the liver suggests that the protein product has an important role in transport of specific molecule(s) into or out of this tissue.   


Article / Publication Details

First-Page Preview
Abstract of Gene Mapping, Cloning and Sequencing

Published online: 6/28/2001

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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References

  1. Allikmets R, Gerrard B, Hutchinson A, Dean M: Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database. Hum molec Genet 5:1649–1655 (1996).
  2. Berge KE, Tian H, Graf GA, Yu L, Grishin NV, Schultz J, Kwiterovich P, Shan B, Barnes R, Hobbs HH: Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. Science 290:1771–1775 (2000).
  3. Bodzioch M, Orso E, Klucken J, Langmann T, Bottcher A, Diederich W, Drobnik W, Barlage S, Buchler C, Porsch-Ozcurumez M, Kaminski WE, Hahmann HW, Oette K, Rothe G, Aslanidis C, Lackner KJ, Schmitz G: The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease. Nature Genet 22:347–351 (1999).
  4. Brooks-Wilson A, Marcil M, Clee SM, Zhang LH, Roomp K, van Dam M, Yu L, Brewer C, Collins JA, Molhuizen HO, Loubser O, Ouelette BF, Fichter K, Ashbourne-Excoffon KJ, Sensen CW, Scherer S, Mott S, Denis M, Martindale D, Frohlich J, Morgan K, Koop B, Pimstone S, Kastelein JJ, Hayden MR, et al: Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency. Nature Genet 22:336–345 (1999).
  5. Dean M, Allikmets R: Evolution of ATP-binding cassette transporter genes. Curr Opin Genet Dev 5:79–785 (1995).

    External Resources

  6. Decottignies A, Goffeau A: Complete inventory of the yeast ABC proteins. Nature Genet 15:137–145 (1997).
  7. Gerloff T, Stieger B, Hagenbuch B, Madon J, Landmann L, Roth J, Hofmann AF, Meier PJ: The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver. J biol Chem 273:10046–10050 (1998).
  8. Klucken JCB, Ors E, Kaminski WE, Porsch-Ozcurumez M, Liebisch G, Kapinsky M, Diederich W, Drobnik W, Dean M, Allikmets R, Schmitz G: ABCG1 (ABC8) the human homolog of the Drosophila white gene is a regulator of macrophage cholesterol and phospholipid transport. Proc natl Acad Sci, USA 97:817–822 (2000).
  9. Lee MH, Lu K, Hazard S, Yu H, Shulenin S, Hidaka H, Kojima H, Allikmets R, Sakuma N, Pegoraro R, Srivastava AK, Salen G, Dean M, Patel SB: Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption. Nature Genet 27:79–83 (2001).
  10. Michaelis S, Berkower C: Sequence comparison of yeast ATP binding cassette (ABC) proteins. Cold Spring Harbor Symposium (Cold Spring Harbor Laboratory Press, (Cold Spring Harbor 1995).
  11. Muller M, Jansen PL: The secretory function of the liver: new aspects of hepatobiliary transport. J Hepatol 28:344–354 (1998).
  12. Patel SB, Salen G, Hidaka H, Kwiterovich PO, Stalenhoef AF, Miettinen TA, Grundy SM, Lee MH, Rubenstein JS, Polymeropoulos MH, Brownstein MJ: Mapping a gene involved in regulating dietary cholesterol absorption. The sitosterolemia locus is found at chromosome 2p21, J Clin Invest 102: 1041–1044 (1998).
  13. Rabindran SK, Ross DD, Doyle LA, Yang W, Greenberger LM: Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein. Cancer Res 60:47–50 (2000).
  14. Remaley AT, Rust S, Rosier M, Knapper C, Naudin L, Broccardo C, Peterson KM, Koch C, Arnould I, Prades C, Duverger N, Funke H, Assman G, Dinger M, Dean M, Chimini G, Santamarina-Fojo S, Fredrickson DS, Denefle P, Brewer HB Jr: Human ATP-binding cassette transporter 1 (ABC1): genomic organization and identification of the genetic defect in the original Tangier disease kindred. Proc natl Acad Sci, USA 96:12685–12690 (1999).
  15. Rust S, Rosier M, Funke H, Real J, Amoura Z, Piette JC, Deleuze JF, Brewer HB, Duverger N, Denefle P, Assmann G: Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1. Nature Genet 22:352–355 (1999).
  16. Salen G, Shefer S, Nguyen L, Ness GC, Tint GS, Batta AK: Sitosterolemia. Subcell Biochem 28:453–476 (1997).
  17. Strautnieks S, Bull LN, Knisely AS, Kocoshis SA, Dahl N, Arnell H, Sokal E, Dahan K, Childs S, Ling V, Tanner MS, Kagalwalla AF, Nemeth A, Pawlowska J, Baker A, Mieli-Vergani G, Freimer NB, Gardiner RM, Thompson RJ: A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis. Nature Genet 20:233–238 (1998).