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Vol. 92, No. 3-4, 2001
Issue release date: 2001
Cytogenet Cell Genet 92:320–325 (2001)
(DOI:10.1159/000056921)

Cloning and chromosome mapping of human and chicken Iroquois (IRX) genes

Ogura K. · Matsumoto K. · Kuroiwa A. · Isobe T. · Otoguro T. · Jurecic V. · Baldini A. · Matsuda Y. · Ogura T.
aGraduate School of Biological Sciences, Nara Institute of Science and Technology, Nara; bLaboratory of Cytogenetics, Division of Bioscience, Graduate School of Environmental Earth Science; cChromosome Research Unit, Faculty of Science, Hokkaido University, Sapporo (Japan); dUniversity of Miami, School of Medicine, Sylvester Cancer Center Division for Clinical and Translational Research, Miami FL; eDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX (USA)

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Abstract

Three highly homologous homeobox genes (caupolican, araucan and mirror) have been identified in Drosophila. These genes belong to the novel Iroquois complex, which acts as a pre-pattern molecule in Drosophila neurogenesis. Recently several vertebrate Iroquois homologues (Irx) were isolated and found to be involved in pattern formation of various tissues. Here we report cytogenetic mapping of four human and five chicken Iroquois genes by FISH. Our findings revealed that vertebrate Irx genes are clustered at two different loci.    



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