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Vol. 93, No. 1-2, 2001
Issue release date: 2001
Section title: Gene Mapping, Cloning and Sequencing
Cytogenet Cell Genet 93:40–42 (2001)
(DOI:10.1159/000056945)

Genomic organization and mapping of the gene (SLC25A19) encoding the human mitochondrial deoxynucleotide carrier (DNC)

Iacobazzi V. · Ventura M. · Fiermonte G. · Prezioso G. · Rocchi M. · Palmieri F.
Departments of aPharmaco-Biology and bPathological Anatomy and Genetics, University of Bari, Bari (Italy)

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Article / Publication Details

First-Page Preview
Abstract of Gene Mapping, Cloning and Sequencing

Published online: 7/19/2001

Number of Print Pages: 3
Number of Figures: 3
Number of Tables: 1

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR

Abstract

The deoxynucleotide carrier (DNC) transports deoxynucleotides into mitochondria and is therefore essential for mtDNA synthesis. The human DNC gene (SLC25A19) spans about 16.5 kb and consists of nine exons with the translation start site in exon 4. It is located on chromosome 17q25.3. Three transcripts, which differ in their 5′ ends and are generated by alternative splicing, have been identified.   


Article / Publication Details

First-Page Preview
Abstract of Gene Mapping, Cloning and Sequencing

Published online: 7/19/2001

Number of Print Pages: 3
Number of Figures: 3
Number of Tables: 1

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

References

  1. Cozens AL, Runswick MJ, Walker JE: DNA sequence of two expressed nuclear genes for human mitochondrial ADP/ATP translocase. J molec Biol 206:261–280 (1990).
  2. Dolce V, Fiermonte G, Runswick MJ, Palmieri F, Walker JE: The human mitochondrial deoxynucleotide carrier and its role in toxicity of nucleoside antivirals. Proc natl Acad Sci, USA 98:2284–2288 (2001).
  3. Dolce V, Iacobazzi V, Palmieri F, Walker JE: The sequences of human and bovine genes of the phosphate carrier from mitochondria contain evidence of alternatively spliced forms. J biol Chem 269:10451–10460 (1994).

    External Resources

  4. Fiermonte G, Dolce V, Arrigoni R, Runswick MJ, Walker JE, Palmieri F: Organization and sequence of the gene for the human mitochondrial dicarboxylate carrier: evolution of the carrier family. Biochem J 3:953–960 (1999).

    External Resources

  5. Iacobazzi V, Palmieri F, Runswick MJ, Walker JE: Sequences of the human and bovine genes for the mitochondrial 2-oxoglutarate carrier. DNA Sequence 3:79–88 (1992).
  6. Iacobazzi V, Lauria G, Palmieri F: Organization and sequence of the human gene for the mitochondrial citrate transport protein. DNA Sequence 73:127–139 (1997).
  7. Iacobazzi V, Naglieri MA, Stanley CA, Wanders RJ, Palmieri F: The structure and organization of the human carnitine/acylcarnitine translocase (CACT) gene. Biochem biophys Res Commun 252:770–774 (1998).
  8. Palmieri F: Mitochondrial carrier proteins. FEBS Lett 346:48–54 (1994).
  9. Palmieri F, van Ommen B: The mitochondrial carrier protein family, in Papa S, et al (eds): Frontiers of Cellular Bioenergetics, pp 489–519 (Kluwer Academic/Plenum Publishers, New York 1999).
  10. Palmieri L, Lasorsa FM, Vozza A, Agrimi G, Fiermonte G, Runswick MJ, Walker JE, Palmieri F: Identification and functions of new transporters in yeast mitochondria. Biochim biophys Acta 1459:363–369 (2000).

    External Resources

  11. Ricquier D, Casteilla L, Bouillard F: Molecular study of the uncoupling protein. FASEB J 5:2237–2242 (1991).

    External Resources

  12. Viggiano L, Iacobazzi V, Marzella R, Cassano C, Rocchi M, Palmieri F: Assignment of the carnitine/acylcarnitine translocase gene (CACT) to human chromosome band 3p21.31 by in situ hybridization. Cytogenet Cell Genet 79:62–63 (1997).

    External Resources