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Vol. 95, No. 1-2, 2001
Issue release date: 2001
Cytogenet Cell Genet 95:79–81 (2001)

The assignment of PRKCI to bovine chromosome 1q34→q36 by FISH suggests a new assignment to human chromosome 3

De Donato M. · Gallagher Jr. D.S. · Davis S.K. · Stelly D.M. · Taylor J.F.
aDepartamento de Biomedicina, IIBCA, Universidad de Oriente, Cumana (Venezuela) bLaboratory of Genetics, Department of Animal Science and cLaboratory of Plant Molecular Cytogenetics, Department of Soil and Crop Sciences, Texas A&M University, College Station, Texas (USA)

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Two bovine BAC clones were identified by PCR as containing the bovine gene PRKCI. Both clones were assigned by FISH to bands q34→q36 on BTA1. The sequence information derived from genomic DNA and from both clones was identical and showed a high degree of homology to human PRKCI (HSAXq21.3, 95.5% homology), and mouse Prkcl (MMU3, 13.8 cM, 87.6% homology) and rat Prkcl (88.8% homology). This assignment could suggest a disruption of the synteny conservation of mammalian X-linked genes, but most likely suggests a misassignment of this gene to the human X.   

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