To view the fulltext, please log in
To view the pdf, please log in
Two bovine BAC clones were identified by PCR as containing the bovine gene PRKCI. Both clones were assigned by FISH to bands q34→q36 on BTA1. The sequence information derived from genomic DNA and from both clones was identical and showed a high degree of homology to human PRKCI (HSAXq21.3, 95.5% homology), and mouse Prkcl (MMU3, 13.8 cM, 87.6% homology) and rat Prkcl (88.8% homology). This assignment could suggest a disruption of the synteny conservation of mammalian X-linked genes, but most likely suggests a misassignment of this gene to the human X.
Copyright / Drug Dosage
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
- De Donato M, Gallagher DS Jr, Davis SK, Ji Y, Burzlaff JD, Stelly DM, Womack JE, Taylor JF: Physical assignment of microsatellite-containing BACs to bovine chromosomes. Cytogenet Cell Genet 87:59–61 (1999).
- Gallagher DS Jr, Davis SK, De Donato M, Burzlaff JD, Womack JE, Taylor JF: A molecular cytogenetic analysis of the tribe Bovini (Artiodactyla: Bovidae: Bovinae) with an emphasis on sex chromosome morphology and NOR distribution. Chrom Res 7:481–492 (1999).
- Hayes H, Le Chalony C, Goubin G, Mercier D, Payen EJ, Bignon C, Kohno K: Localization of ZNF164, ZNF146, GGTA1, SOX2, PRLR and EEF2 on homeologous cattle, sheep and goat chromosomes by fluorescent in situ hybridization and comparison with the human gene map. Cytogenet Cell Genet 72:342–346 (1996).
- ISCNDA: International system for cytogenetic nomenclature of domestic animals. Cytogenet Cell Genet 53:65–79 (1989).
- Mazzarella R, Ciccodicola A, Esposito T, Arcucci A, Migliaccio C, Jones C, Schlessinger D, D’Urso M, D’Esposito M: Human protein kinase c iota gene (PRKCI) is closely linked to the BTK gene in Xq21.3. Genomics 26:629–631 (1995).
- Ohno S: Ancient linkage groups and frozen accidents. Nature 244:259–262 (1973).
- Oullette BFF, Bogusi MS: Database divisions and homology search files: a guide for the perplexed. Genome Res 7:952–955 (1997).
- Quaderi NA, Gianfrancesco F, Brown SD, D’Urso M, D’Esposito M: Genetic mapping of a gene encoding an atypical protein kinase C, protein kinase C lambda, to the proximal region of mouse chromosome 3. Genomics 29:815–816 (1995).
- Schibler L, Vaiman D, Oustry A, Giraud-Delville C, Cribiu E: Comparative gene mapping: a fine-scale survey of chromosome rearrangements between ruminants and humans. Genome Res 8:901–915 (1998).
- Shimizu N, Shimizu Y, Kondo I, Woods C, Wegner T: The bovine genes for phosphoglycerate kinase, glucose-6-phosphate dehydrogenase, alpha-galactosidase, and hypoxanthine phosphoribosyltransferase are linked to the X chromosome in cattle-mouse cell hybrids Cytogenet Cell Genet 29:26–33 (1981).
- Threadgill DS, Womack JE: Mapping HSA 3 loci in cattle: Additional support for the ancestral synteny of HSA 3 and 21. Genomics 11:1143–1148 (1991).