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Table of Contents
Vol. 95, No. 3-4, 2001
Issue release date: 2001
Cytogenet Cell Genet 95:153–156 (2001)
(DOI:10.1159/000059338)

A novel LPP fusion gene indicates the crucial role of truncated LPP proteins in lipomas and pulmonary chondroid hamartomas

Lemke I. · Rogalla P. · Bullerdiek J.
Center of Human Genetics, University of Bremen, Bremen (Germany)

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Abstract

The lipoma preferred partner (LPP) gene is fused to the high mobility group protein gene HMGIC in lipomas and pulmonary chondroid hamartomas. In addition, a fusion of LPP to the mixed lineage leukemia (MLL) gene has been described in a case of acute myeloid leukemia. Herein, a novel LPP fusion transcript of LPP in a lipoma is described that points to the possible oncogenic potential of LPP.   



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References

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  3. Lemke I, Rogalla P, Bullerdiek J: Large deletion of part of the HMGA2 locus accompanying a t(3;12)(q27→q28;q14→q15) in lipoma. Cancer Genet Cytogenet 129:161–164 (2001).

    External Resources

  4. Petit MMR, Mols R, Schoenmakers EFPM, Mandahl N, Van de Ven WJM: LLP, the preferred fusion partner gene of HMGIC in lipomas, is a novel member of the LIM protein gene family. Genomics 36:118–129 (1996).

    External Resources

  5. Petit MM, Fradelizi J, Golsteyn RM, Ayoubi TA, Menichi B, Louvard D, Van de Ven WJ, Friederich E: LPP, an actin cytoskeleton protein related to zyxin, harbors a nuclear export signal and transcriptional activation capacity. Mol Biol Cell 11:117–129 (2000).
  6. Rogalla P, Kazmierczak B, Meyer-Bolte K, Tran KH, Bullerdiek J: The t(3;12)(q27;q14→15) with underlying HMGA2-LPP fusion is not determining an adipocytic phenotype. Genes Chrom Cancer 22:100–104 (1998).
  7. Rogalla P, Lemke I, Kazmierczak B, Bullerdiek J: An identical HMGA2-LPP fusion transcript is consistently expressed in pulmonary chondroid hamartomas with t(3;12)(q27→q28;q14→q15). Genes Chrom Cancer 29:363–366 (2000).
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    External Resources

  9. Schoenmakers EFPM, Wanschura S, Mols R, Bullerdiek J, Van den Berghe H, Van de Ven W: Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours. Nature Genet 10:436–444 (1995).

    External Resources

  10. Schoenmakers EF, Huysmans C, Van de Ven WJ: Allelic knockout of novel splice variants of human recombination repair gene RAD51B in t(12;14) uterine leiomyomas. Cancer Res 59:19–23 (1999).

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