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A novel LPP fusion gene indicates the crucial role of truncated LPP proteins in lipomas and pulmonary chondroid hamartomas

Lemke I. · Rogalla P. · Bullerdiek J.
Center of Human Genetics, University of Bremen, Bremen (Germany) Cytogenet Cell Genet 95:153–156 (2001) (DOI:10.1159/000059338)

Abstract

The lipoma preferred partner (LPP) gene is fused to the high mobility group protein gene HMGIC in lipomas and pulmonary chondroid hamartomas. In addition, a fusion of LPP to the mixed lineage leukemia (MLL) gene has been described in a case of acute myeloid leukemia. Herein, a novel LPP fusion transcript of LPP in a lipoma is described that points to the possible oncogenic potential of LPP.   

 

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