Vol. 45, No. 2, 2002
Issue release date: March–April 2002 (July 2002)
Intervirology 2002;45:101–104
Short Communication
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Genotyping of Hepatitis E Virus from Vietnam

Hijikata M.a · Hayashi S.b · Trinh N.T.e · Ha L.D.e · Ohara H.c · Shimizu Y.K.a · Keicho N.a · Yoshikura H.d
aDepartment of Respiratory Diseases, Research Institute, bDepartment of Gastroenterology, cBureau of International Cooperation, International Medical Center of Japan, dNational Institute of Infectious Diseases, Tokyo, Japan; eThe Institute for Clinical Research in Tropical Medicine, Bach Mai Hospital, Hanoi, Vietnam
email Corresponding Author

 goto top of outline Key Words

  • Hepatitis E virus
  • Genotype
  • Vietnam

 goto top of outline Abstract

To identify the genotype of Vietnamese isolates of human hepatitis E virus (HEV), phylogenetic analysis was performed for the open reading frame (ORF) 1 and ORF2 nucleotide sequences of the viral genome. HEV was detected by RT-PCR in 9 out of 141 sera collected from patients with a diagnosis of acute sporadic hepatitis in Hanoi, Vietnam. All of them had sequences related most closely to genotype 4. In addition, the Vietnamese isolate had a single nucleotide insertion in the ORF 3 region, a characteristic reported for genotype 4 with the possible change of initiation of ORF 3 and ORF 2.

Copyright © 2002 S. Karger AG, Basel

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  9. Hsieh SY, Yang PY, Ho YP, Chu CM, Liaw YF: Identification of a novel strain of hepatitis E virus responsible for sporadic acute hepatitis in Taiwan. J Med Virol 1998;55:300–304.

 goto top of outline Author Contacts

Minako Hijikata, MD
Department of Respiratory Diseases
Research Institute, International Medical Center of Japan
1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655 (Japan)
Tel. +81 3 3202 7181 (ext. 2875), Fax +81 3 3207 1038, E-Mail minakoh@ri.imcj.go.jp

 goto top of outline Article Information

Received: Received: December 17, 2001
Accepted after revision: January 21, 2002
Number of Print Pages : 4
Number of Figures : 2, Number of Tables : 0, Number of References : 9

 goto top of outline Publication Details

Intervirology (International Journal of Basic and Medical Virology)
Founded 1973 by J.L. Melnick; continued by F. Rapp (1986–1990); M.J. Buchmeier and C.R. Howard (1991–1993)

Vol. 45, No. 2, Year 2002 (Cover Date: March-April 2002 (Released July 2002))

Journal Editor: Rüdiger W. Braun, Stuttgart
ISSN: 0300–5526 (print), 1423–0100 (Online)

For additional information: http://www.karger.com/journals/int

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