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Vol. 92, No. 2, 2002
Issue release date: October 2002
Nephron 2002;92:459–462

Role of Ribavirin in Membranoproliferative Glomerulonephritis Associated with Hepatitis C Virus Infection Refractory to Alpha-Interferon

Pérez-Calvo J. · Lasierra P. · Moros M. · Iñigo P.
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Chronic hepatitis C virus (HCV) has been associated with several extrahepatic diseases, such as membranoproliferative glomerulonephritis (MPGN). α-Interferon is currently the treatment of choice for this association. When this therapy fails clinicians face a difficult challenge due to the lack of useful information in these particularly difficult patients. We report the case of a severe nephrotic syndrome due to MPGN associated HCV infection, in which a triple association – interferon plus ribavirin and cyclophosphamide – was needed to control the disease.

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