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Insulin and Insulin-Like Growth Factor I Receptors: Similarities and Differences in Signal Transduction

Dupont J. · LeRoith D.
Clinical Endocrinology Branch, NIDDK, Bethesda, Md., USA Horm Res 2001;55(suppl 2):22–26 (DOI:10.1159/000063469)


The insulin receptor (IR) and the insulin-like growth factor I receptor (IGF-IR) belong to the same subfamily of receptor tyrosine kinases with two extracellular α-subunits and two transmembrane β-subunits. They share a high similarity of structure and intracellular signalling events. However, the IR and the IGF-IR mediate different effects on metabolism, cell proliferation, apoptosis and differentiation. Although some of the variation can be attributed to a different tissue distribution or subcellular localization, it can also be explained by structural differences in the β-subunit, which may result in activation of specific substrates and signal pathways.


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