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Vol. 71, No. 4, 2002
Issue release date: July–August 2002
Section title: Special Article
Psychother Psychosom 2002;71:180–189
(DOI:10.1159/000063642)

The Somatics of Psyche: Structural Neuromorphometry of Bipolar Disorder

Benabarre A. · Vieta E. · Martinez-Arán A. · Reinares M. · Colom F. · Lomeña F. · Martin F. · Valdés M.
Bipolar Disorders Program and Nuclear Medicine Department, Barcelona Stanley Foundation Research Center, Hospital Clinic, University of Barcelona, IDIBAPS, Barcelona, Spain

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Article / Publication Details

First-Page Preview
Abstract of Special Article

Published online: 7/1/2002

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 2

ISSN: 0033-3190 (Print)
eISSN: 1423-0348 (Online)

For additional information: http://www.karger.com/PPS

Abstract

Many neuroimaging investigations report structural differences in subjects with bipolar disorder; however, conflicting results are common in the limited number of available investigations. Thus, the structural correlates of bipolar disorders remain poorly understood. The authors reviewed the early investigations using computed tomography and examined gross structural differences, such as cerebral atrophy, ventricular enlargement, or cerebellar atrophy. Many of these investigations report significant differences in these features compared with controls, whereas others found no such differences. More recent magnetic resonance imaging (MRI) investigations have employed increasingly sophisticated imaging and research methodologies, allowing for the quantitative examination of specific brain regions. Because neuropsychological and functional studies suggest abnormalities in frontal, temporal and subcortical regions, many investigators have focused their MRI neuromorphometric studies on these temporal limbic structures. However, the number of investigations examining each of these regions remains small, and conflicting results continue to be reported. It seems clear that for many brain regions, the structural changes from normal may be subtle, and that the differences in the reported studies may be due to differences in research methodologies between studies and across centers.


Article / Publication Details

First-Page Preview
Abstract of Special Article

Published online: 7/1/2002

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 2

ISSN: 0033-3190 (Print)
eISSN: 1423-0348 (Online)

For additional information: http://www.karger.com/PPS


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References

  1. Pearlson GD: Structural and functional brain changes in bipolar disorder: A selective review. Schizophr Res 1999;39:133–140.
  2. Nasrallah HA, McCalley-Whitters M, Jacoby CG: Cerebral ventricular enlargement in young manic males. A controlled CT study. J Affect Disord 1982;4:15–19.
  3. Luchins DJ, Lewine RRJ, Meltzer HY: Lateral ventricular size, psychopathology, and medication response in psychoses. Biol Psychiatry 1984;19:29–44.

    External Resources

  4. Scott ML, Golden CJ, Ruedrich SL, Bishop RJ: Ventricular enlargement in major depression. Psychiatry Res 1983;8:91–93.
  5. Shima S, Shikamo T, Kitamura T, Masuda Y, Tsukumo T, Kanba S, Asai M: Depression and ventricular enlargement. Acta Psychiatr Scand 1984;70:275–277.

    External Resources

  6. Schlegel S, Kretzschmar K: Computed tomography in affective disorders. I: Ventricular and sulcal measurements. Biol Psychiatry 1987;22:4–14.
  7. Jacoby RJ, Levy R: Computed tomography in the elderly. 3: Affective disorders. Br J Psychiatry 1980;136:270–275.

    External Resources

  8. Targum SD, Rosen LN, DeLisi LE, Weimberger DR, Citrin CM: Cerebral ventricular size in major depressive disorder: Association with delusional symptoms. Biol Psychiatry 1983;18:329–336.

    External Resources

  9. Sachetti E, Vita A, Comte G, et al: Brain morphology in major affective disorders: Clinical and biological correlates. Proc Int Meet Plasticity Morphol CNS, Milan, October 1987, pp 49–51.
  10. Jeste DV, Lohr JB, Goodwin FK: Neuroanatomical studies of major affective disorders. A review and suggestions for further research. Br J Psychiatry 1988;153:444–459.
  11. Swayze VW 2nd, Andreasen NC, Alliger RJ, et al: Structural brain abnormalities in bipolar affective disorder. Ventricular enlargement and focal signal hyperintensities. Arch Gen Psychiatry 1990;47:1054–1059.
  12. Strakowski SM, Wilson DR, Tohen M, Woods BT, Douglass AW, Stoll AL: Structural brain abnormalities in first-episode mania. Biol Psychiatry 1993;33:602–609.
  13. Elkis H, Friedman L, Wise A, Meltzer HY: Meta-analyses of studies of ventricular enlargement and cortical sulcal prominence in mood disorders. Comparisons with controls or patients with schizophrenia. Arch Gen Psychiatry 1995;52:735–746.
  14. Botteron KN, Figiel GS: The neuromorphometry of affective disorders; in Rama KR, Doraiswamy PM (eds): Brain Imaging in Clinical Psychiatry. New York, Dekker 1997, pp 146–176.
  15. Iacono WG, Smith GN, Moreau M, Beiser M, Fleming JAE, Lin T, Flak B: Ventricular and sulcal size at the onset of psychosis. Am J Psychiatry 1988;145:820–824.
  16. Dewan MJ, Haldipur CV, Lane EE, Ispahani A, Boucher MF, Major LF: Bipolar affective disorder. I. Comprehensive quantitative computed tomography. Acta Psychiatr Scand 1988;77:670–676.

    External Resources

  17. Rieder RO, Mann LS, Weinberger DR, et al: Computed tomographic scans in patients with schizophrenia, schizoaffective, and bipolar affective disorder. Arch Gen Psychiatry 1983;40:735–739.

    External Resources

  18. Zubenko GS, Sullivan P, Nelson JP, et al: Brain imaging abnormalities in mental disorders of late life. Arch Neurol 1990;47:1107–1111.
  19. Tanaka Y, Hazama H, Fukuhara T, Tsutsui T: Computerized tomography of the brain in manic-depressive patients – a controlled study. Folia Psychiatr Neurol Jpn 1982;36:137–143.

    External Resources

  20. Benes FM, Swigar ME, Rothman SLG, Opsahl C, Dowds M: CT scan studies of superficial cerebral regions: Frequency and distribution of abnormalities in elderly psychiatric patients. Neurobiol Aging 1983;4:289–295.
  21. Rothschild AJ, Benes F, Hebben N, et al: Relationships between brain CT scan findings and cortisol in psychotic and nonpsychotic depressed patients. Biol Psychiatry 1989;26:565–575.
  22. Nasrallah HA, Olson SC, Schwarzkopf SB: Diminished brain volume in bipolar disorder. Annu Meet Am Coll Neuropsychopharmacol, San Juan, Dec 1990.
  23. Coffey CE, Wilkinson WE, Weiner RD, Parashos IA, Djang WT, Webb MC, Figiel GS, Spritzer CE: Quantitative cerebral anatomy in depression. A controlled magnetic resonance imaging study. Arch Gen Psychiatry 1993;50:7–16.
  24. Swayze VW 2nd, Andreasen NC, Alliger RJ, Yuh WT, Ehrhardt JC: Subcortical and temporal structures in affective disorder and schizophrenia: A magnetic resonance imaging study. Biol Psychiatry 1992;31:221–240.
  25. Hauser P, Dauphinais D, Berrettini W, et al: Corpus callosum dimensions measured by magnetic resonance imaging in bipolar affective disorder and schizophrenia. Biol Psychiatry 1989;26:659–668.
  26. Altshuler LL, Conrad A, Hauser P, Li XM, Guze BH, Denikoff K, Tourtellotte W, Post R: Reduction of temporal lobe volume in bipolar disorder: A preliminary report of magnetic resonance imaging. Arch Gen Psychiatry 1991;48:482–483.
  27. Olson SC, Bogerts B, Coffman JA: Medial-temporal and ventricular abnormalities by MRI: Comparing major psychoses. Biol Psychiatry 1990;27:59A–60A.
  28. Young RC, Nambudiri DE, Jain H, de Asis JM, Alexopoulos GS: Brain computed tomography in geriatric manic disorder. Biol Psychiatry 1999;15;45:1063–1065.
  29. Weinberger DR, DeLisi LE, Perman GP, et al: Computed tomography in schizophreniform disorder and other acute psychiatric disorders. Arch Gen Psychiatry 1982;39:778–783.

    External Resources

  30. Heath RG, Franklin DE, Walker CF, Keating JW Jr: Cerebellar vermal atrophy in psychiatric patients. Biol Psychiatry 1982;17:569–583.

    External Resources

  31. Lippmann S, Manshadi M, Baldwin H, Drasin G, Rice J, Alrajeh S: Cerebellar vermis dimensions on computerized tomographic scans of schizophrenic and bipolar patients. Am J Psychiatry 1982;139:667–668.

    External Resources

  32. Nasrallah HA, Jacoby CG, McCalley-Whitters M: Cerebellar atrophy in schizophrenia and mania. Lancet 1981;i:1102.
  33. Loeber RT, Sherwood AR, Renshaw PF, Cohen BM, Yurgelun-Todd DA: Differences in cerebellar blood volume in schizophrenia and bipolar disorder. Schizophr Res 1999;4:37:81–89.
  34. DelBello MP, Strakowski SM, Zimmerman ME, Hawkins JM, Sax KW: MRI analysis of the cerebellum in bipolar disorder: A pilot study. Neuropsychopharmacology 1999;21:63–68.
  35. Hauser P, Altshuler LL, Berrettini W, Dauphinais ID, Gelernter J, Post RM: Temporal lobe measurement in primary affective disorder by magnetic resonance imaging. J Neuropsychiatry Clin Neurosci 1989;1:128–134.
  36. Husain MM, Figiel GS, Lurie SN, et al: MRI of corpus callosum and septum pellucidum in depression. Biol Psychiatry 1991;29:300–301.
  37. Coffman JA, Bornstein RA, Olson SC, Schwarzkopf SB, Nasrallah HA: Cognitive impairment and cerebral structure by MRI in bipolar disorder. Biol Psychiatry 1990;27:1188–1196.
  38. Wu JC, Buchsbaum MS, Johnson JC, Hershey TG, Wagner EA, Teng C, Lottenberg S: Magnetic resonance and positron emission tomography imaging of the corpus callosum: Size, shape and metabolic rate in unipolar depression. J Affect Disord 1993;28:15–25.
  39. Dupont RM, Jernigan TL, Butters N, et al: Subcortical abnormalities detected in bipolar affective disorder using magnetic resonance imaging. Clinical and neuropsychological significance. Arch Gen Psychiatry 1990;47:55–59.
  40. Figiel GS, Krishnan KRR, Rao VP, et al: Subcortical hyperintensities on brain magnetic resonance imaging: A comparison of normal and bipolar subjects. J Neuropsychiatry Clin Neurosci 1991;3:18–22.
  41. Brown R, Colter N, Corsellis JA, et al: Postmortem evidence of structural brain changes in schizophrenia: Differences in brain weight, temporal horn area, and parahippocampal gyrus compared with affective disorder. Arch Gen Psychiatrry 1986;43:36–42.
  42. Dupont RM, Jernigan TL, Heindel W, Butters N, Shafer K, Wilson T, Hesselink J, Gillin JC: Magnetic resonance imaging and mood disorders. Localization of white matter and other subcortical abnormalities. Arch Gen Psychiatry 1995;52:747–755.
  43. Botteron KN, Vannier MW, Geller B, Todd R, Lee BC: Preliminary study of magnetic resonance imaging characteristics in 8- to 16-year olds with mania. J Am Acad Child Adolesc Psychiatry 1995;34:742–749.
  44. Aylward EH, Roberts-Twillie JV, Barta PE, Kumar AJ, Harris GJ, Geer M, Peyser CE, Pearlson GD: Basal ganglia volumes and white matter hyperintensities in patients with bipolar disorder. Am J Psychiatry 1994;151:687–693.
  45. Krabbendam L, Honig A, Wiersma J, Vuurman EF, Hofman PA, Derix MM, Nolen WA, Jolles J: Cognitive dysfunctions and white matter lesions in patients with bipolar disorder in remission. Acta Psychiatr Scand 2000;101:274–280.
  46. Fazekas F, Kleinert R, Offenbacher H, Payer F, Schmidt R, Kleinert G, Radner H, Lechner H: The morphologic correlate of incidental punctate white matter hyperintensities on MR images. AJNR Am J Neuroradiol 1991;12:915–921.
  47. Awad IA, Johnson PC, Spetzler RJ, Hodak JA: Incidental subcortical lesions identified on magnetic resonance imaging in the elderly. II: Postmortem pathological correlations. Stroke 1986;17:1090–1097.
  48. Moore PB, El-Badri SM, Cousins D, Shepherd DJ, Young AH, McAllister VL, Ferrier IN: White matter lesions and season of birth of patients with bipolar affective disorder. Am J Psychiatry 2001;158:1521–1524.
  49. Ribeiro SCM, Tandon R, Grunhaus L, Greden JF: The DST as a predictor of outcome in depression: A meta-analysis. Am J Psychiatry 1993;150:1618–1629.
  50. Cosgriff JP, Abbott RM, Oakley-Browne MA, Joyce PR: Cortisol hypersecretion predicts early depressive relapse after recovery with electroconvulsive therapy. Biol Psychiatry 1990;28:1007–1010.
  51. Banki CM, Karmacsi L, Bissette G, Nemeroff CB: CSF corticotropin-releasing hormone and somatostatin in major depression: Response to antidepressant treatment and relapse. Eur Neuropsychopharmacol 1992;2:107–113.
  52. Hatterer JA, Kocsis JH, Stokes PE: Thyroid function in patients maintained on lithium. Psychiatry Res 1988;26:249–257.
  53. Vieta E, Gastó C, Martínez de Osaba MJ, Nieto E, Cantó TJ, Otero A, Vallejo J: Prediction of depressive relapse in remitted bipolar patients using corticotropin-releasing hormone challenge test. Acta Psychiatr Scand 1997;95:205–211.
  54. Vieta E, Martínez-de-Osaba MJ, Colom F, Martínez-Aràn A, Benabarre A, Gastó C: Enhanced corticotropin response to corticotropin-releasing hormone as a predictor of mania in euthymic bipolar patients. Psychol Med 1999;29:971–978.
  55. Xu Y, Jack CR, O’Brien PC, Kokmen E, Smith GE, Ivnik RJ, Boeve BF, Tangalos RG, Petersen RC: Usefulness of MRI measures of entorhinal cortex versus hippocampus in AD. Neurology 2000;54:1760–1767.
  56. Krishnan KRR, Doraiswamy PM, Lurie SN, et al: Pituitary size in depression. J Clin Endocrinol Metab 1991;72:256–259.
  57. Krishnan KRR, Doraiswamy PM, Figiel GS, Husain MM, Shah SA, Na C, Boyko OB, McDonald WM, Nemeroff CB, Ellinwood EH Jr: Hippocampal abnormalities in depression. J Neuropsychiatry Clin Neurosci 1991;3:387–391.
  58. Altshuler LL, Bartzokis G, Grieder T, Curran J, Jimenez T, Leight K, Wilkins J, Gerner R, Mintz J: An MRI study of temporal lobe structures in men with bipolar disorder or schizophrenia. Biol Psychiatry 2000;15;48:147–162.
  59. Strakowski SM, DelBello MP, Sax KW, Zimmerman ME, Shear PK, Hawkins JM, Larson ER: Brain magnetic resonance imaging of structural abnormalities in bipolar disorder. Arch Gen Psychiatry 1999;56:254–260.
  60. Ali SO, Denicoff KD, Altshuler LL, Hauser P, Li X, Conrad AJ, Mirsky AF, Smith-Jackson EE, Post RM: A preliminary study of the relation of neuropsychological performance to neuroanatomic strucutres in bipolar disorder. Neuropsychiatry Neuropsychol Behav Neurol 2000;13:20–28.
  61. Husain MM, McDonald WM, Draiswamy PM, Figiel GS, Na C, Escalona PR, Boyko OB, Nemeroff CB, Krishnan KRR: A magnetic resonance imaging study of putamen nuclei in major depression. Psychiatry Res 1991;40:95–99.
  62. Sandyk R: The relationship of pineal calcification to subtypes of tardive dyskinesia in bipolar patients. Int J Neurosci 1990;54:307–313.

    External Resources

  63. Schneider G, Kruse A, Nehen HG, Senf W, Heuft G: The prevalence and differential diagnosis of subclinical depressive syndromes in inpatients 60 years and older. Psychother Psychosom 2000;69:251–260.
  64. Soares JC, Krishnan KR, Keshavan MS: Nuclear magnetic resonance spectroscopy: New insights into the pathophysiology of mood disorders. Depression 1996;4:14–30.
  65. Kennedy SH, Javanmard M, Vaccarino FJ: A review of functional neuroimaging in mood disorders: Positron emission tomography and depression. Can J Psychiatry 1997;42:467–475.
  66. Steffens DC, Krishnan KR: Structural neuroimaging and mood disorders: Recent findings, implications for classification, and future directions. Biol Psychiatry 1998;43:705–712.
  67. Martínez-Arán A, Vieta E, Colom F, Benabarre A, Reinares M, Gastó C, Salamero M: Cognitive dysfunctions in bipolar disorder: Evidence of neuropsychological disturbances. Psychother Psychosom 2000;69:2–18.
  68. Martínez Aràn A, Penadés R, Vieta E, Colom F, Reinares M, Benabarre A, Salamero M, Gastó C: Executive function in patients with remitted bipolar disorder and schizophrenia and its relationship with functional outcome. Psychother Psychosom 2002;71:39–46.
  69. Brown FW, Lewine RJ, Hudgins PA, Risch SC: White matter hyperintensity signals in psychiatric and nonpsychiatric subjects. Am J Psychiatry 1992;149:620–625.
  70. Johnstone EC, Owens DG, Crow TJ, Frith CD, Alexandropolis K, Bydder G, Colter N: Temporal lobe structure as determined by nuclear magnetic resonance in schizophrenia and bipolar affective disorder. J Neurol Neurosurg Psychiatry 1989;52:736–741.

    External Resources