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Vol. 15, No. 5, 2002
Issue release date: September–October 2002
Section title: Paper
Skin Pharmacol Appl Skin Physiol 2002;15:374–380
(DOI:10.1159/000064544)

Emblica Cascading Antioxidant: A Novel Natural Skin Care Ingredient

Chaudhuri R.K.
Rona/EM Industries, Inc., Hawthorne, N.Y., USA

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 9/16/2002

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 2

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP

Abstract

A standardized extract of Phyllanthus emblica (trade named Emblica) was found to have a long-lasting and broad-spectrum antioxidant activity. The product has no pro-oxidation activity induced by iron and/or copper because of its iron and copper chelating ability. Emblica helps protect the skin from the damaging effects of free radicals, non-radicals and transition metal-induced oxidative stress. Emblica is suitable for use in anti-aging, sunscreen and general purpose skin care products.


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 9/16/2002

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 2

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

References

  1. Bast A, Haenen GRMM, Doelman CJA: Oxidants and antioxidants: State of the art. Am J Med 1991;91 (suppl 3C): 2S–13S.
  2. Bissett DL, McBride JF: Chronic ultraviolet radiation-induced increase in skin iron and the photoprotective effect of topically applied iron chelators. J Soc Cosmet Chem 1992;43:215–217.
  3. Brenneisen P, Wenk J, Klotz LO, Wlaschek M, Briviba K, Krieg T, Sies H, Scharfetter-Kochanek K: Central role of Ferrous/Ferric iron in the ultraviolet B irradiation-mediated signaling pathway leading to increased interstitial collagenase (matrix-degrading metalloprotease (MMP)-1) and stromelysin-1 (MMP-3) mRNA levels in cultured human dermal fibroblasts. J Biol Chem 1998;273:5279–5287.
  4. Chopra RN, Nayar SL, Chopra IC: Glossary of Indian Medicinal Plants. New Delhi, CSIR, 1956.
  5. Ghosal S: US Patent 6,124,268 (2000).
  6. Ghosal S, Tripathi VK, Chauhan S: Active constituents of Emblica officinalis. 1. The chemistry and antioxidant activity of two new hydrolysable tannins, emblicanin A and B. Indian J Chem 1996;35B: 941–948.
  7. Graf E, Mahoney JR, Byrant RG, Eaton JW: Iron-catalyzed hydroxyl radical formation. Stringent requirement for free iron coordination site. J Biol Chem 1984;259:3620–3624.
  8. Halliwell B, Gutteridge JMC: Free Radicals in Biology and Medicine, ed 3. Oxford, Oxford University Press, 1999, p 53.
  9. Kato K, Terao S, Shimamoto N, Hirata M: Studies on scavengers of active oxygen species. 1. Synthesis and biological activity of 2-O-alkylascorbic acids. J Med Chem 1988;31:793–798.

    External Resources

  10. Martell AE, Gustafson R, Chaberek S: in Farkas A (ed): Advances in Catalysis. New York, Academic Press, 1957, vol 9, p 319.
  11. Monograph on Emblica (Merck KGaA, Darmstadt, Germany, 2001).
  12. Ohkawa H, Ohishi N, Yagi K: Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979;95:351–358.
  13. Pourzand C, Watkin RD, Brown JE, Tyrrell RM: Ultraviolet A radiation induces immediate release of iron in human primary skin fibroblasts: The role of ferritin. Proc Natl Acad Sci USA 1999;96:6751–6756.
  14. Richard M-J, Guiraud P, Monjo A-M, Favier A: Development of a simple antioxidant screening assay using human skin fibroblasts. Free Radic Res Commun 1992:16:303–314.
  15. Sreejayan, Rao MNA: Curcumin inhibits iron-dependant lipid peroxidation. Indian J Pharmacol 1993;100:93–97.