Journal Mobile Options
Table of Contents
Vol. 9, No. 4, 2002
Issue release date: July–August 2002
Section title: Original Paper
J Biomed Sci 2002;9:359–364
(DOI:10.1159/000065007)

Abnormal Measles-Mumps-Rubella Antibodies and CNS Autoimmunity in Children with Autism

Singh V.K. · Lin S.X. · Newell E. · Nelson C.
Department of Biology and Biotechnology Center, Utah State University, Logan, Utah, USA

Do you have an account?

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger (new!)
  • Unrestricted printing, no saving restrictions for personal use
  • Reduced rates with a PPV account
read more

Direct: USD 38.00
Account: USD 26.50

Select

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restriction apply

Rental: USD 8.50
Cloud: USD 20.00

Select

Subscribe

  • Automatic perpetual access to all articles of the subscribed year(s)
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 7/19/2002

Number of Print Pages: 6
Number of Figures: 5
Number of Tables: 0

ISSN: 1021-7770 (Print)
eISSN: 1423-0127 (Online)

For additional information: http://www.karger.com/JBS

Abstract

Autoimmunity to the central nervous system (CNS), especially to myelin basic protein (MBP), may play a causal role in autism, a neurodevelopmental disorder. Because many autistic children harbor elevated levels of measles antibodies, we conducted a serological study of measles-mumps-rubella (MMR) and MBP autoantibodies. Using serum samples of 125 autistic children and 92 control children, antibodies were assayed by ELISA or immunoblotting methods. ELISA analysis showed a significant increase in the level of MMR antibodies in autistic children. Immunoblotting analysis revealed the presence of an unusual MMR antibody in 75 of 125 (60%) autistic sera but not in control sera. This antibody specifically detected a protein of 73–75 kD of MMR. This protein band, as analyzed with monoclonal antibodies, was immunopositive for measles hemagglutinin (HA) protein but not for measles nucleoprotein and rubella or mumps viral proteins. Thus the MMR antibody in autistic sera detected measles HA protein, which is unique to the measles subunit of the vaccine. Furthermore, over 90% of MMR antibody-positive autistic sera were also positive for MBP autoantibodies, suggesting a strong association between MMR and CNS autoimmunity in autism. Stemming from this evidence, we suggest that an inappropriate antibody response to MMR, specifically the measles component thereof, might be related to pathogenesis of autism.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 7/19/2002

Number of Print Pages: 6
Number of Figures: 5
Number of Tables: 0

ISSN: 1021-7770 (Print)
eISSN: 1423-0127 (Online)

For additional information: http://www.karger.com/JBS


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

References

  1. Buttram HE. Vaccine scene 2000 – Review and update. Med Sentinel 5:49–52;2000.
  2. Chess S, Fernandez P, Korn S. Behavioral consequences of congenital rubella. J Pediatr 93:699–703;1978.
  3. Cohen S, Miller GE, Rabin BS. Psychological stress and antibody response to immunization: A critical review of the human literature. Psychosom Med 63:7–18;2001.

    External Resources

  4. Comi AM, Zimmerman AW, Frye VH, Law PA, Peeden JN. Familial clustering of autoimmune disorders and evaluation of medical risk factors in autism. J Child Neurol 14:388–394;1999.
  5. Fudenberg HH. Dialyzable lymphocyte extract (DLyE) in infantile onset autism: A pilot study. Biotherapy 9:143–147;1996.

    External Resources

  6. Fujinaga T, Motegi Y, Tamura H, Kuroume T. A prefecture-wide survey of mumps meningitis associated with measles, mumps and rubella vaccine. Pediatr Infect Dis J 10:204–209;1991.

    External Resources

  7. Gupta S, Aggarwal S, Heads C. Dysregulated immune system in children with autism: Beneficial effects of intravenous immune globulin on autistic characteristics. J Autism Dev Disord 26:439–452;1996.
  8. Ivarsson A, Bjerre I, Vegfors P, Ashfors K. Autism as one of several disabilities in two children with congenital cytomegalovirus infection. Neuropediatrics 21:102–103;1989.
  9. Madhur G. Indian scientists warn of ‘mutant measles’ virus. BMJ 322:693;2001.
  10. Menage P, Thibault G, Barthelemy C, Lelord G, Bardos P. CD+ CD45RA+ T lymphocyte deficiency in autistic children: Effect of a pyridoxine-magnesium treatment. Brain Dysfunct 5:326–333;1992.
  11. Plesner AM, Hansen FJ, Taudorf K, Nielsen LH, Larsen CB, Pedersen E. Gait disturbance interpreted as cerebellar ataxia after MMR vaccination at 15 months of age: A follow up study. Acta Paediatr 89:58–63;2000.

    External Resources

  12. Plioplys AV, Greaves A, Kazemi K, Silverman E. Lymphocyte function in autism and Rett syndrome. Neuropsychobiology 29:12–16;1994.

    External Resources

  13. Shoenfeld Y, Aron-Maor A. Vaccination and autoimmunity – ‘Vaccinosis’: A dangerous liaison? J Autoimmun 14:1–10;2000.
  14. Singh VK. Plasma increase of interleukin-12 and interferon-gamma: Pathological significance in autism. J Neuroimmunol 66:143–145;1996.

    External Resources

  15. Singh VK. Neuro-immunopathogenesis in autism. In: Berczi I, Gorczynski R, eds. Neuroimmune Biology: New Foundation of Biology. New York, Elsevier Science BV, 447–458;2001.
  16. Singh VK, Warren RP, Cole P, Odell JD. Abnormalities of interleukin-2 production and levels of IgG isotypes in autistic patients (abstract 1569). FASEB J 3:A496;1989.
  17. Singh VK, Lin SY, Yang VC. Serological association of measles virus and human herpesvirus-6 with brain autoantibodies in autism. Clin Immunol Immunopathol 89:105–108;1998.
  18. Singh VK, Tingle AJ. Detection of circulating immune complexes by a C1q-microplate ELISA system. J Immunol Methods 50:109–114;1982.
  19. Singh VK, Warren RP, Averett R, Ghaziuddin M. Circulating autoantibodies to neuronal and glial filament proteins in autism. Pediatr Neurol 16:88–90;1997.

    External Resources

  20. Singh VK, Warren RP, Odell JD, Cole P, Warren L. Antibodies to myelin basic protein in children with autistic disorder. Brain Behav Immun 7:97–103;1993.
  21. Stubbs EG, Crawford ML, Burger DR, Vanderbark AA. Depressed lymphocyte responsiveness in autistic children. J Autism Child Schizophr 7:49–55;1977.
  22. Wakefield AJ, Murch SH, Anthony A, Linnell J, Casson DM, Malik M, Berelowitz M, Dhillon AP, Thompson MA, Harvey P, Valentine A, Davies SE, Walker-Smith JA. Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. Lancet 351:637–641;1998.
  23. Warren RP, Foster A, Margaretten NC. Reduced natural killer cell activity in autism. J Am Acad Child Adolesc Psychiatry 26:333–335;1987.

    External Resources

  24. Warren RP, Singh VK, Averett RE, Odell JD, Maciulis A, Burger RA, Daniels WW, Warren WL. Immunogenetic studies in autism and related disorders. Mol Chem Neuropathol 28:77–81;1996.

    External Resources