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Vol. 35, No. 2-3, 2002
Issue release date: March–June 2002
Section title: Conceptual Bases for the Development of Future Diagnostic Systems
Psychopathology 2002;35:139–144
(DOI:10.1159/000065134)

Neuroscience, Genetics, and the Future of Psychiatric Diagnosis

Hyman S.E.
Harvard University, Cambridge, Mass., USA

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Article / Publication Details

First-Page Preview
Abstract of Conceptual Bases for the Development of Future Diagnostic Systems

Published online: 7/17/2002

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0254-4962 (Print)
eISSN: 1423-033X (Online)

For additional information: http://www.karger.com/PSP

Abstract

Nearly three decades after Robins and Guze’s seminal delineation of the steps required to validate a psychiatric diagnosis, a pathophysiologically based classification of psychiatric disorders remains elusive. Contrary to optimistic expectations, approaches to diagnostic validity based on clinical description, laboratory studies, natural history of illness, and familial aggregation have not converged to yield a nosology based on valid disease entities. Defining a rational nosology for disorders of the brain, the body’s most complex organ, is clearly one of the great challenges for modern medical science. Nonetheless, fundamental advances in our understanding of the genetic and environmental determinants of disease risk, and of the neural circuitry supporting normal and pathological mental processes promises to form the basis of improved classification in the coming decades.


Article / Publication Details

First-Page Preview
Abstract of Conceptual Bases for the Development of Future Diagnostic Systems

Published online: 7/17/2002

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0254-4962 (Print)
eISSN: 1423-033X (Online)

For additional information: http://www.karger.com/PSP


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References

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    External Resources

  10. Robins E, Guze SB: Establishment of diagnostic validity in psychiatric illness: Its application to schizophrenia. Am J Psychiatry 1970;126:983–987.
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