Blood Purif 2002;20:445–450

From Erythropoietin to Oxygen: Hypoxia-Inducible Factor Hydroxylases and the Hypoxia Signal Pathway

Ratcliffe P.J.
Renal and Cell Physiology Group, The Henry Wellcome Building of Genomic Medicine, University of Oxford, UK
email Corresponding Author

 goto top of outline Key Words

  • Erythropoietin
  • Hypoxia-inducible factor
  • Prolyl hydroxylase
  • Oxygen sensing

 goto top of outline Abstract

The regulation of blood red cell production by the hormone erythropoietin (Epo) provides a paradigm for control of gene expression by oxygen. Analysis of this pathway has revealed a widespread system of gene regulation based on a transcriptional complex termed hypoxia-inducible factor (HIF). Hydroxylation of specific prolyl and asparinyl residues in the α subunit of HIF by a series of non-haem iron-dependent dioxygenases has been defined as a novel mechanism of protein modification that transduces the oxygen-sensitive signal.

Copyright © 2002 S. Karger AG, Basel

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 goto top of outline Author Contacts

Peter J. Ratcliffe
The Henry Wellcome Building of Genomic Medicine
University of Oxford, Roosevelt Drive
Oxford OX3 7BN (UK)

 goto top of outline Article Information

Number of Print Pages : 6
Number of Figures : 1, Number of Tables : 0, Number of References : 49

 goto top of outline Publication Details

Blood Purification (Official Journal of the International Society of Blood Purification (ISBP))
Founded 1983; edited by K. Schaefer (1983–1988)
Official Journal of the International Society of Blood Purification

Vol. 20, No. 5, Year 2002 (Cover Date: 2002)

Journal Editor: L.W. Henderson, McGaw Park, Ill.
ISSN: 0253–5068 (print), 1421–9735 (Online)

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