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Table of Contents
Vol. 63, No. 4, 2002
Issue release date: November 2002
Section title: Review
Oncology 2002;63:317–332
(DOI:10.1159/000066230)

The Role of the IGF System in Cancer: From Basic to Clinical Studies and Clinical Applications

Moschos S.J. · Mantzoros C.S.
Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass., USA

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Article / Publication Details

First-Page Preview
Abstract of Review

Published online: 11/7/2002

Number of Print Pages: 16
Number of Figures: 1
Number of Tables: 2

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL

Abstract

Insulin-like growth factors (IGFs) are important mediators of growth, development, and survival, are synthesized by almost any tissue in the body, and their action is modulated by a complex network of molecules, including binding proteins, proteases and receptors, which all comprise the IGF system. Evidence from in vitro and animal studies suggests that overexpression of IGFs by cancer cells and/or the nearby stroma as well as the type IGF-I receptor by the cancer cells may play a significant role in establishing a transformed phenotype in an increasing number of malignancies. More specifically, IGFs may promote cell cycle progression and inhibition of apoptosis either by directly associating with other growth factors or indirectly by interacting with other molecular systems which have an established role in carcinogenesis and cancer promotion, such as the steroid hormones and integrins. In addition, a growing number of epidemiologic studies suggest that increased serum levels of IGFs and/or altered levels of their binding proteins are associated with increased risk for developing several malignancies. These data indicate that IGF dysregulation should now be considered as an important independent factor for cancer risk, and a potential target for novel antineoplastic therapies and/or preventative strategies in high-risk groups.


Article / Publication Details

First-Page Preview
Abstract of Review

Published online: 11/7/2002

Number of Print Pages: 16
Number of Figures: 1
Number of Tables: 2

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL


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