Table of Contents
To view the fulltext, log-in or choose pay-per-view options:
Get Access

Enhanced Epileptogenic Susceptibility in a Genetic Model of Reactive Synaptogenesis: The Spastic Han-Wistar Rat

Cepeda C.a · Crawford C.A.b · Margulies J.E.c · Watson J.B.a · Levine M.S.a · Cohen R.W.d
aMental Retardation Research Center, University of California, Los Angeles; bDepartment of Psychology, California State University, San Bernardino; cDepartment of Surgery, Cedars-Sinai Medical Center, Los Angeles, and dDepartment of Biology, California State University, Northridge, Calif., USA Dev Neurosci 2002;24:262–271 (DOI:10.1159/000066740)

Abstract

Our laboratory has been studying the spastic Han-Wistar (sHW) rat as a model of neuronal degeneration. Mutant sHW rats display a number of developmental abnormalities that eventually lead to hippocampal pyramidal cell death and synaptic reorganization starting around 30 days of age. The present study examined the contribution of hippocampal reorganization to the expression of seizures induced by systemic injections of kainic acid. Behavioral observations, EEG recordings and hippocampal Fos protein expression in these animals indicated that mutants develop paroxysmal discharges and seizures earlier than controls and the intensity of epileptic manifestations is greater. Kainate injections were lethal in 50% of mutants compared to only 5% of controls. Fos expression was increased approximately twofold in the mutant hippocampus, implicating abnormal excitation in this region. Additional studies in untreated animals indicated that GluR2 mRNA expression was significantly increased throughout the hippocampus in mutant animals, possibly contributing to the enhanced susceptibility to kainate treatment. These results confirm the role of synaptic reorganization in the increased propensity to develop epileptic discharges. Our data also underscore the usefulness of this natural model of cell degeneration and reactive synaptogenesis for understanding the mechanisms of neuronal hyperexcitability.

 

Individual Users: Register with Karger Login Information

Please create your User ID & Password





Contact Information











I have read the Karger Terms and Conditions and agree.


Pay-per-View Options
Direct payment This item at the regular price: USD 9.00
Payment from account With a Karger Pay-per-View account (down payment USD 150) you profit from a special rate for this and other single items.
This item at the discounted price: USD 8.00