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Vol. 83, No. 1, 2003
Issue release date: January 2003
Section title: Original Paper
Biol Neonate 2003;83:1–5
(DOI:10.1159/000067005)

Can the Administration of Antithrombin III Decrease the Risk of Cerebral Hemorrhagein Premature Infants?

Fulia F. · Cordaro S. · Meo P. · Gitto P. · Gitto E. · Trimarchi G. · Adelardi S. · Barberi I.
aNeonatal Intensive Care Unit, Department of Pediatrics, and bInstitute of Statistics, University of Messina, Italy

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 5/22/2002
Published online: 1/17/2003

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 3

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO

Abstract

This study was carried out to determine whether the administration of antithrombin III decreases the risk of intraventricular hemorrhage in premature infants. In a randomized study, 60 infants born before 30 weeks of gestation were assigned to receive a loading dose of antithrombin III or placebo. There was no significant difference in the incidence of intraventricular hemorrhage between the antithrombin III and the placebo group (27.5 vs. 32%). Partial thromboplastin time, Quick’s prothrombin time and platelet count were also not significantly different between the 2 groups. We conclude that the administration of antithrombin III during the first 2 days of life does not decrease incidence of intraventricular hemorrhage. Antithrombin III is a very expensive therapy and its benefits should be carefully investigated before being recommended as valuable therapy.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 5/22/2002
Published online: 1/17/2003

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 3

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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