Table of Contents
To view the fulltext, log-in or choose pay-per-view options:
Get Access

Role of Serine/Threonine Protein Phosphatase in Alzheimer’s Disease

Tian Q. · Wang J.
Pathophysiology Department, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China Neurosignals 2002;11:262–269 (DOI:10.1159/000067425)


Accumulating evidence indicates that serine/threonine (Ser/Thr) protein phosphatases (PPs), such as PP1, PP2A and PP2B, participate in the neurodegenerative progress in Alzheimer’s disease (AD). The general characteristics and pathologic changes of PP1, PP2A and PP2B in AD, and their relations with microtubule-associated proteins, focusing mainly on τ protein, neurofilament (NF), amyloid precursor protein (APP) processing and synaptic plasticity are discussed. Deriving novel insight into the particular topic will attract greater attention to more active investigation and effective therapeutic intervention in the future.


Individual Users: Register with Karger Login Information

Please create your User ID & Password

Contact Information

I have read the Karger Terms and Conditions and agree.

Pay-per-View Options
Direct payment This item at the regular price: USD 38.00
Payment from account With a Karger Pay-per-View account (down payment USD 150) you profit from a special rate for this and other single items.
This item at the discounted price: USD 26.50