Login to MyKarger

New to MyKarger? Click here to sign up.

Login with Facebook

Forgot Password? Reset your password

Authors, Editors, Reviewers

For Manuscript Submission, Check or Review Login please go to Submission Websites List.

Submission Websites List

Institutional Login (Shibboleth)

For the academic login, please select your country in the dropdown list. You will be redirected to verify your credentials.

Table of Contents
Vol. 1, No. 1, 2003
Issue release date: 2003
Section title: Original Research Paper
Complexus 2003;1:38–44

Modeling of Protein Interaction Networks

Vázquez A.a · Flammini A.a · Maritan A.a,b · Vespignani A.b
aInternational School for Advanced Studies and INFM and bThe Abdus Salam International Centre for Theoretical Physics, Trieste, Italy
email Corresponding Author

Amos Maritan

SISSA, Via Beirut 2–4

I–34014 Trieste (Italy)

Tel. + 39 040 2240462, Fax + 39 040 3787528

E-Mail maritan@sissa.it


  1. Uetz PL, et al: A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae. Nature 2000;403:623.
  2. Wagner A: The yeast protein interaction network evolves rapidly and contains few redundant duplicate genes. Mol Biol Evol 2001;18:1283–1292.
  3. Jeong H, Mason SP, Barabsi A-L, Oltvai ZN: Lethality and centrality in protein networks. Nature 2001; 411:41.
  4. Watts DJ, Strogatz SH: Collective dynamics of ‘small-world networks. Nature 1998;393:440.
  5. Barabsi A-L, Albert R: Emergence of scaling in random networks. Science 1999;286:509.
  6. Strogatz SH: Exploring complex networks. Nature 2001;410:268.
  7. Albert R, Barabsi A-L: Topology of evolving networks: Local events and universality. Phys Rev Lett 2000;85:5234.
  8. Krapivsky PL, Redner S, Leyvraz F: Connectivity of growing random networks. Phys Rev Lett 2000;85: 4629.
  9. Dorogovtsev SN, Mendes JFF: Scaling behaviour of developing and decaying networks. Europhys Lett 2000;52:33.
  10. Force A, Lynch M, Pickett, FB, Amores A, Yan Y-I, Postlethwait J: The preservation of duplicate genes by complementary degenerative mutations. Genetics 1999;151:1531.
  11. Lynch M, Force A: The probability of duplicate-gene preservation by subfunctionalization. Genetics 2000; 154:459.
  12. http://www.biotech.nature.com/web_extras.
  13. Henikoff S, Greene EA, Pietrokovski S, Bork P, Attwood TK, Hood L: Gene families: The taxonomy of protein paralogs and chimeras. Science 1997;278:609.
  14. Tatusov RL, Koonin EV, Lipman DJ: A genomic perspective on protein families. Science 1997;278:631.
  15. Ohno S: Evolution by Gene Duplication. Berlin, Springer, 1970.
  16. Phizicky EM, Fields S: Protein-protein interactions: Methods for detection and analysis. Microbiol Rev 1995;59:94.
  17. von Mering C, Krause R, Snel B, Cornell M, Oliver SG, Fields S, Bork P: Comparative assessment of large-scale data sets of protein-protein interactions. Nature 2002;417:399.
  18. Yook S-H, Oltvai ZN, Barabsi A-L: Functional and topological characterization of protein interaction networks. Preprint.
  19. Huynen MA, Bork P: Measuring genome evolution. Proc Natl Acad Sci USA 1998;95:5849.
  20. Dorogovtsev SN, Mendes JFF, Samukhin AN: Multifractal properties of growing networks. Europhys Lett 2002;57:334.
  21. Albert R, Barabsi A-L: Statistical mechanics of complex networks. Rev Mod Phys 2001;74:47.
    External Resources
  22. Dorogovtsev SN, Mendes JFF: Evolution of networks. Adv Phys 2002;51:1079.
  23. Vzquez A, Flammini A, Maritan A, Vespignani A: Modeling of protein interaction networks. In preparation.
  24. Dorogovtsev SN, Mendes JFF: Evolution of networks with aging of sites. Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics 2000;62:1842.
  25. Krapivsky PL, Redner S: Organization of growing random networks. Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics 2001;63:066123.
    External Resources
  26. Newman MEJ, Strogatz SH, Watts DJ: Random graphs with arbitrary degree distributions and their applications. Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics 2001;64:026118.
    External Resources
  27. Albert RA, Jeong H, Barabsi A-L: Error and attack tolerance of complex networks. Nature 2000;406:378.
  28. Callaway DS, Newman MEJ, Strogatz SH, Watts DJ: Network robustness and fragility: Percolation on random graphs. Phys Rev Lett 2000;85:5468.
  29. Cohen R, Erez K, ben-Avraham D, Havlin S: Breakdown of the internet under intentional attack. Phys Rev Lett 2001;86:3682.
  30. Solé RV, Pastor-Satorras R, Smith ED, Kepler T: A model of large-scale proteome evolution. Adv Comp Syst 2002;5:43.