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Table of Contents
Vol. 45, No. 4-6, 2002
Issue release date: July–December 2002 (January 2003)
Section title: Hantavirus
Intervirology 2002;45:318–327
(DOI:10.1159/000067924)

Emerging Viruses: The Case ‘Hantavirus’

Ulrich R.a · Hjelle B.b · Pitra C.c · Krüger D.H.a
aInstitute of Virology, Humboldt University, Charité Medical School, Berlin, Germany; bDepartment of Pathology, University of New Mexico, Albuquerque,N.Mex., USA; cDepartment of Evolutionary Genetics, Institute for Zoo Biology and Wildlife Research, Berlin,Germany
email Corresponding Author

Abstract

This review briefly summarises the recent knowledge about hantavirus infections and raises particular problems in hantavirus research that need further investigation. The following questions are addressed: (i) are hantaviruses distributed worldwide and what leads to new outbreaks, (ii) what is known about hantavirus evolution, (iii) how can hantavirus species be defined, (iv) what are the determinants of hantavirus pathogenesis in humans, and (v) what problems are associated with the development of new vaccines and antiviral therapeutics.

© 2003 S. Karger AG, Basel


  

Key Words

  • Hantavirus
  • Bunyaviridae
  • Emerging viruses
  • Rodents
  • Evolution
  • Pathogenesis
  • Vaccine

References

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    External Resources

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    External Resources

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    External Resources

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    External Resources

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Author Contacts

Dr. Detlev H. Krüger
Institute of Virology
Humboldt University, School of Medicine Charité
D–10098 Berlin (Germany)
Tel. +49 30 450 525092, Fax +49 30 450 525907, E-Mail detlev.kruger@charite.de

  

Article Information

Number of Figures : 0, Number of Tables : 1, Number of References : 87

  

Publication Details

Intervirology (International Journal of Basic and Medical Virology)
Founded 1973 by J.L. Melnick; continued by F. Rapp (1986–1990); M.J. Buchmeier and C.R. Howard (1991–1993)

Vol. 45, No. 4-6, Year 2002 (Cover Date: July-December 2002 (Released January 2003))

Journal Editor: Rüdiger W. Braun, Stuttgart
ISSN: 0300–5526 (print), 1423–0100 (Online)

For additional information: http://www.karger.com/journals/int


Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

Abstract

This review briefly summarises the recent knowledge about hantavirus infections and raises particular problems in hantavirus research that need further investigation. The following questions are addressed: (i) are hantaviruses distributed worldwide and what leads to new outbreaks, (ii) what is known about hantavirus evolution, (iii) how can hantavirus species be defined, (iv) what are the determinants of hantavirus pathogenesis in humans, and (v) what problems are associated with the development of new vaccines and antiviral therapeutics.

© 2003 S. Karger AG, Basel


  

Author Contacts

Dr. Detlev H. Krüger
Institute of Virology
Humboldt University, School of Medicine Charité
D–10098 Berlin (Germany)
Tel. +49 30 450 525092, Fax +49 30 450 525907, E-Mail detlev.kruger@charite.de

  

Article Information

Number of Figures : 0, Number of Tables : 1, Number of References : 87

  

Publication Details

Intervirology (International Journal of Basic and Medical Virology)
Founded 1973 by J.L. Melnick; continued by F. Rapp (1986–1990); M.J. Buchmeier and C.R. Howard (1991–1993)

Vol. 45, No. 4-6, Year 2002 (Cover Date: July-December 2002 (Released January 2003))

Journal Editor: Rüdiger W. Braun, Stuttgart
ISSN: 0300–5526 (print), 1423–0100 (Online)

For additional information: http://www.karger.com/journals/int


Article / Publication Details

First-Page Preview
Abstract of Hantavirus

Published online: 1/30/2003
Issue release date: July–December 2002 (January 2003)

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 1

ISSN: 0300-5526 (Print)
eISSN: 1423-0100 (Online)

For additional information: http://www.karger.com/INT


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

References

  1. Krüger DH, Ulrich R, Lundkvist Å: Hantavirus infections and their prevention. Microbes Infect 2001;3:1129–1144.
  2. Schmaljohn CS, Nichol ST (eds): Hantaviruses. Curr Top Microbiol Immunol. Berlin, Springer, 2001, vol 256.
  3. Lee HW, Lee PW, Johnson KM: Isolation of the etiologic agent of Korean hemorrhagic fever. J Infect Dis 1978;137:298–308.
  4. Yanagihara R: Hantavirus infection in the United States: Epizootiology and epidemiology. Rev Infect Dis 1990;12:449–457.
  5. Johnson KM: Hantaviruses: History and overview. Curr Top Microbiol Immunol 2001;256:1–14.
  6. Gonzalez JP, Josse R, Johnson ED, Merlin M, Georges AJ, Abandja J, Danyod M, Delaporte E, Dupont A, Ghogomu A, et al: Antibody prevalence against haemorrhagic fever viruses in randomised representative Central African populations. Res Virol 1989;140:319–331.
  7. Rodier G, Soliman AK, Bouloumie J, Kremer D: Presence of antibodies to hantavirus in rat and human populations of Djibouti. Trans R Soc Trop Med Hyg 1993;87:160–161.
  8. Gajdusek DC: Muroid virus nephropathies and muroid viruses of the Hantaan virus group. Scand J Infect Dis Suppl 1982;36:96–108.
  9. LeDuc JW, Smith GA, Childs JE, Pinheiro FP, Maiztegui JI, Niklasson B, Antoniades A, Robinson DM, Khin M, Shortridge KF, et al: Global survey of antibody to Hantaan-related viruses among peridomestic rodents. Bull World Health Organ 1986;64:139–144.
  10. Lundkvist Å, Hukic M, Hörling J, Gilljam M, Nichol S, Niklasson B: Puumala and Dobrava viruses cause hemorrhagic fever with renal syndrome in Bosnia-Herzegovina: Evidence of highly cross-neutralizing antibody responses in early patient sera. J Med Virol 1997;53:51–59.
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