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Vol. 18, No. 2, 2003
Issue release date: March–April 2003
Fetal Diagn Ther 2003;18:65–82

History of Fetal Diagnosis and Therapy: Children’s Hospital of Philadelphia Experience

Hedrick H.L. · Flake A.W. · Crombleholme T.M. · Howell L.J. · Johnson M.P. · Wilson R.D. · Adzick N.S.
Center for Fetal Diagnosis and Treatment, Children’s Hospital of Philadelphia, and Department of Surgery and Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pa., USA

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Since its inception in 1995, the mission of the Center for Fetal Diagnosis and Treatment at the Children’s Hospital of Philadelphia (CHOP) has been to provide comprehensive, multidisciplinary expertise in all facets of prenatal diagnosis, reproductive genetics, and prenatal, perinatal, and postnatal treatment for abnormal fetuses. Most of the authors were trained and/or served on faculty at centers in San Francisco (N.S.A., A.W.F., T.M.C., L.J.H.) or Detroit (A.W.F, M.P.J.). Accurate prenatal detection by serial sonographic study and the development of ultrafast magnetic resonance imaging (MRI) scanners has permitted delineation of the natural history of anatomic malformations. Definition of the pathophysiological features that affect clinical outcome and formulation of management based on prognosis has allowed families to make informed decisions. Outcomes have been improved through carefully planned and coordinated perinatal management. In some cases of life-threatening or severely debilitating defects, prenatal surgery has been offered.

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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