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Vol. 49, No. 4, 2003
Issue release date: May 2003
Section title: Original Paper
Eur Neurol 2003;49:218–222
(DOI:10.1159/000070187)

Glutathione S-Transferase Polymorphisms: Susceptibility to Migraine without Aura

Kusumi M. · Ishizaki K. · Kowa H. · Adachi Y. · Takeshima T. · Sakai F. · Nakashima K.
aDepartment of Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Yonago, and bDepartment of Neurology, Kitasato University, Sagamihara, Japan

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 12/10/2001
Accepted: 12/4/2002
Published online: 5/14/2003

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 4

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: http://www.karger.com/ENE

Abstract

Migraine is considered to be a polygenic multifactorial disease with various environmental and genetic etiologies. We investigated glutathione S-transferase (GST) P1 Ile105Val, T1 and M1 polymorphisms in 174 Japanese headache sufferers and 372 Japanese controls. The headache group consisted of 38 cases of migraine with aura, 95 migraine without aura (MWOA) and 41 tension-type headache sufferers. The M1 homozygous deletion genotype was significantly higher in MWOA (64%) compared with controls (46%; p < 0.01; odds ratio = 2.18, 95% confidence interval: 1.32–3.61, adjusted for age and gender). In a comparison of the current smokers, the M1 null frequencies in MWOA were further increased. GSTM1 may be one of the genetic risk factors for MWOA in the Japanese population.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 12/10/2001
Accepted: 12/4/2002
Published online: 5/14/2003

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 4

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: http://www.karger.com/ENE


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

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