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Vol. 12, No. 2, 2003
Issue release date: March–April 2003
Section title: Original Paper
Neurosignals 2003;12:89–94
(DOI:10.1159/000071818)

Cerebroventricular Administration of Interferon-Gamma Modifies Locomotor Activity in the Golden Hamster

Boggio V.I. · Castrillón P.O. · Perez Lloret S. · Riccio P. · Esquifino A.I. · Cardinali D.P. · Cutrera R.A.
a Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina; bDepartamento de Bioquímica y Biología Molecular III, Facultad de Medicina, Universidad Complutense, Madrid, Spain

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 2/18/2003
Accepted: 4/17/2003
Published online: 7/25/2003

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 1

ISSN: 1424-862X (Print)
eISSN: 1424-8638 (Online)

For additional information: http://www.karger.com/NSG

Abstract

The present study was undertaken to examine whether the intracerebroventricular (i.c.v.) administration of interferon (IFN)-gamma could modify 24-hour wheel running locomotor activity in the golden hamster. Hamsters implanted with a cannula in the third ventricle received a single i.c.v. injection of 1 µl of murine recombinant IFN-gamma (40 IU/µl) or its vehicle (saline) at ZT 6 or ZT 18 (with ZT 12 defined arbitrarily as the time of lights off) and their activities were monitored during 24 h. The i.c.v. administration of IFN-gamma at ZT 6 produced a significant phase advance in acrophase of rhythm, an effect not seen at ZT 18. Also, IFN-gamma depressed mesor value significantly, the effect was seen at both times. These results clearly showed that the circadian clock could be modified by IFN-gamma microinjections. One explanation could be the presence of IFN-gamma receptor in the rat suprachiasmatic nucleus, supporting a direct effect on the central oscillator. However, another hypothesis could not be ruled out.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 2/18/2003
Accepted: 4/17/2003
Published online: 7/25/2003

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 1

ISSN: 1424-862X (Print)
eISSN: 1424-8638 (Online)

For additional information: http://www.karger.com/NSG


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