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Vol. 9, No. 4, 2003
Issue release date: October 2003

Alcohol as a Risk Factor for Global Burden of Disease

Rehm J. · Room R. · Monteiro M. · Gmel G. · Graham K. · Rehn N. · Sempos C.T. · Jernigan D.
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Abstract

Aim: To make quantitative estimates of the burden of disease attributable to alcohol in the year 2000 on a global basis. Design: Secondary data analysis. Measurements: Two dimensions of alcohol exposure were included: average volume of alcohol consumption and patterns of drinking. There were also two main outcome measures: mortality, i.e. the number of deaths, and disability-adjusted life years (DALYs), i.e. the number of years of life lost to premature mortality or to disability. All estimates were prepared separately by sex, age group and WHO region. Findings: Alcohol causes a considerable disease burden: 3.2% of the global deaths and 4.0% of the global DALYs in the year 2000 could be attributed to this exposure. There were marked differences by sex and region for both outcomes. In addition, there were differences by disease category and type of outcome; in particular, unintentional injuries contributed most to alcohol-attributable mortality burden while neuropsychiatric diseases contributed most to alcohol-attributable disease burden. Discussion/Conclusions: The underlying assumptions are discussed and reasons are given as to why the estimates should still be considered conservative despite the considerable burden attributable to alcohol globally.



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References

  1. Murray CJL, Lopez A: Global mortality, disability, and the contribution of risk factors: Global burden of disease study. Lancet 1997;349:1436–1442.
  2. English DR, Holman CDJ, Milne E, Winter MJ, Hulse GK, Codde G, et al: The Quantification of Drug-Caused Morbidity and Mortality in Australia 1995. Canberra, Commonwealth Department of Human Services and Health, 1995.
  3. Single E, Robson L, Rehm J, Xie X: Morbidity and mortality attributable to alcohol, tobacco, and illicit drug use in Canada. Am J Public Health 1999;89:385–390.
  4. Gutjahr E, Gmel G, Rehm J: Relation between average alcohol consumption and disease: An overview. Eur Addict Res 2001;7:117–127.
  5. Ezzati M, Lopez AD, Rodgers A, Vander Horn S, Murray CJL, and the Comparative Risk Assessment Collaborating Group: Selected major risk factors and global and regional burden of disease. Lancet 2002;360:1347–1360.
  6. World Health Organization. World Health Report 2002: Reducing Risks, Promoting Healthy Life. Geneva, WHO, 2002.
  7. Rehm J, Room R, Graham K, Monteiro M, Gmel G, Sempos CT: The relationship of average volume of alcohol consumption and patterns of drinking to burden of disease – An overview. Addiction (in press).
  8. World Health Organization: The World Health Report 2000 – Health Systems: Improving Performance. Geneva, WHO, 2000.
  9. Rehm J, Rehn N, Room R, Monteiro M, Gmel G, Jernigan D, Frick U: The global distribution of average volume of alcohol consumption and patterns of drinking. Eur Addict Res 2003;9:147–156.
  10. Rehm J, Monteiro M, Room R, Gmel G, Jernigan D, Frick U, et al: Steps towards constructing a global comparative risk analysis for alcohol consumption: Determining indicators and empirical weights for patterns of drinking, deciding about theoretical minimum, and dealing with different consequences. Eur Addict Res 2001;7:138–147.
  11. Rehm J, Room R, Monteiro M, Gmel G, Graham K, Rehn N, Sempos CT, Frick U, Jernigan D: Alcohol as a risk factor for burden of disease; in WHO (ed): Comparative quantification of health risks: Global and regional burden of disease due to selected major risk factors. Geneva, WHO, 2003.
  12. Rehm J, Gmel G: Applying principles of comparative risk analysis to substance abuse-related burden. Eur Addict Res 2001;7:95–97.
  13. Single E, Robson L, Xie X, Rehm J: The Cost of Substance Abuse in Canada. Ottawa, Canadian Centre on Substance Abuse, 1996.
  14. Corrao G, Rubbiati L, Bagnardi V, Zambon A, Poikolainen K: Alcohol and coronary heart disease: A meta-analysis. Addiction 2000;95:1505–1523.
  15. Ridolfo B, Stevenson C: The Quantification of Drug-Caused Mortality and Morbidity in Australia, 1998. Canberra, Australian Institute of Health and Welfare, 2001.
  16. Gmel G, Rehm J, Frick U: Trinkmuster, Pro-Kopf-Konsum von Alkohol und koronare Mortalität. Sucht 2003;49:95–104.
  17. Holman CD, English DR, Milne E, Winter MJ: Meta-analysis of alcohol and all-cause mortality: A validation of NHMRC recommendations. Med J Aust 1996;164:141–145.
  18. Rehm J, Gutjahr E, Gmel G: Alcohol and all-cause mortality: A pooled analysis. Contemp Drug Probl 2001;28:337–361.
  19. Sempos CT, Rehm J, Crespo C, Trevisan M: No protective effect of alcohol consumption on coronary heart disease (CHD) in African Americans. Average volume of drinking over the life course and CHD morbidity and mortality in a US national cohort. Contemp Drug Probl 2002;29:805–820.
  20. Sempos CT, Rehm J, Wu T, Crespo C, Trevisan M: Average volume of alcohol consumption and all-cause mortality in African Americans: The NHEFS cohort. Alcohol Clin Exp Res 2003;27:88–92.
  21. Rehm J, Sempos CT, Trevisan M: Average volume of alcohol consumption, patterns of drinking and risk of coronary heart disease – A review. J Cardiovasc Risk 2003;10:15–20.
  22. Murray CJL, Salomon JA, Mathers C: A critical examination of summary measures of population health. Bull WHO 2000;78:981–994.
  23. Murray CJL, Lopez A: The Global Burden of Disease: A comprehensive assessment of mortality and disability from diseases, injuries and risk factors in 1990 and projected to 2020. Boston, Harvard School of Public Health on behalf of the WHO and the World Bank, 1996.
  24. Corrao G, Bagnardi V, Zambon A, Arico S: Exploring the dose-response relationship between alcohol consumption and the risk of several alcohol-related conditions: A meta-analysis. Addiction 1999;94:1551–1573.
  25. Leon DA, Chenet L, Shkolnikov VM, Zakharov S, Shapiro J, Rakhmanova G, Vassin S, McKee M: Huge variation in Russian mortality rates 1984–94:Artefact, alcohol, or what? Lancet 1997;350:383–388.
  26. Edwards G, Anderson P, Babor TF, Casswell S, Ferrence R, Giesbrecht N, et al: Alcohol Policy and the Public Good. Oxford, Oxford University Press, 1994.
  27. Babor T, Caetano R, Casswell S, Edwards G, Giesbrecht N, Graham K, Grube J, Gruenewald P, Hill L, Holder H, Homel R, Österberg E, Rehm J, Room R, Rossow I: Alcohol: No Ordinary Commodity – A Consumer’s Guide to Public Policy. Oxford, Oxford University Press, 2003.
  28. Room R, Graham K, Rehm J, Jernigan D, Monteiro M: Drinking and its burden in a global perspective: Policy considerations and options. Eur Addict Res 2003;9:165–175.
  29. Chisholm D, Rehm J, van Ommeren M, Monteiro M, on behalf of WHO Choice: Averting the burden of heavy alcohol use: A comparative analysis of intervention effectiveness. 2003.


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