Journal Mobile Options
Table of Contents
Vol. 48, No. 2, 2003
Issue release date: September 2003
Neuropsychobiology 2003;48:68–71
(DOI:10.1159/000072879)

Allelic Variants of the Tryptophan Hydroxylase (A218C) and Serotonin 1B Receptor (A-161T) and Personality Traits

Tsai S.-J. · Wang Y.-C. · Chen J.-Y. · Hong C.-J.
aDepartment of Psychiatry, Taipei Veterans General Hospital, bDivision of Psychiatry, School of Medicine, National Yang-Ming University, Taipei, and cSection of Psychiatry, Yu-Li Veterans Hospital, Hualien, Taiwan, ROC

Individual Users: Register with Karger Login Information

Please create your User ID & Password





Contact Information











I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Abstract

Human personality traits have a considerable hereditary component, and central serotonergic activity is implicated in the personality factors of the Tridimensional Personality Questionnaire (TPQ). Our population-based association study tested the hypothesis that the tryptophan hydroxylase (TPH) A218C and serotonin 1B receptor (HTR1B) A-161T polymorphisms were associated with TPQ personality trait scores in a sample population of 209 young healthy Chinese. No significant differences were demonstrated comparing scores of subjects bearing different TPH or HTR1B genotypes; however, a trend for difference in the novelty seeking score comparing TPH genotype groups was determined for the male population. Our negative findings suggest that the TPH A218C and HTR1B polymorphisms do not play major roles in the determination of TPQ personality traits.



Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

References

  1. Cloninger CR: A systematic method for clinical description and classification of personality variants. A proposal. Arch Gen Psychiatry 1987;44:573–588.
  2. Benjamin J, Li L, Patterson C, Greenberg BD, Murphy DL, Hamer DH: Population and familial association between the D4 dopamine receptor gene and measures of Novelty Seeking. Nat Genet 1996;12:81–84.
  3. Ebstein RP, Novick O, Umansky R, Priel B, Osher Y, Blaine D, Bennett ER, Nemanov L, Katz M, Belmaker RH: Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking. Nat Genet 1996;12:78–80.
  4. Nielsen DA, Goldman D, Virkkunen M, Tokola R, Rawlings R, Linnoila M: Suicidality and 5-hydroxyindoleacetic acid concentration associated with a tryptophan hydroxylase polymorphism. Arch Gen Psychiatry 1994;51:34–38.
  5. Nielsen DA, Jenkins GL, Stefanisko KM, Jefferson KK, Goldman D: Sequence, splice site and population frequency distribution analyses of the polymorphic human tryptophan hydroxylase intron 7. Brain Res Mol Brain Res 1997;45:145–148.

    External Resources

  6. Bellivier F, Leboyer M, Courtet P, Buresci C, Beaufils B, Samolyk D, Allilaire JF, Feingold J, Mallet J, Malafosse A: Association between the tryptophan hydroxylase gene and manic-depressive illness. Arch Gen Psychiatry 1998;55:33–37.
  7. Nielsen DA, Virkkunen M, Lappalainen J, Eggert M, Brown GL, Long JC, Goldman D, Linnoila M: A tryptophan hydroxylase gene marker for suicidality and alcoholism. Arch Gen Psychiatry 1998;55:593–602.
  8. New AS, Gelernter J, Yovell Y, Trestman RL, Nielsen DA, Silverman J, Mitropoulou V, Siever LJ: Tryptophan hydroxylase genotype is associated with impulsive-aggression measures: A preliminary study. Am J Med Genet 1998;81:13–17.
  9. Manuck SB, Flory JD, Ferrell RE, Dent KM, Mann JJ, Muldoon MF: Aggression and anger-related traits associated with a polymorphism of the tryptophan hydroxylase gene. Arch Gen Psychiatry 1999;45:603–614.
  10. Moret C, Briley M: The possible role of 5-HT(1B/D) receptors in psychiatric disorders and their potential as a target for therapy. Eur J Pharmacol 2000;404:1–12.
  11. Scearce-Levie K, Chen JP, Gardner E, Hen R: 5-HT receptor knockout mice: Pharmacological tools or models of psychiatric disorders. Ann NY Acad Sci 1999;868:701–715.
  12. Sun HF, Chang YT, Fann CS, Chang CJ, Chen YH, Hsu YP, Yu WY, Cheng AT: Association study of novel human serotonin 5-HT(1B) polymorphisms with alcohol dependence in Taiwanese Han. Biol Psychiatry 2002;51:896–901.
  13. Jonsson EG, Goldman D, Spurlock G, Gustavsson JP, Nielsen DA, Linnoila M, Owen MJ, Sedvall GC: Tryptophan hydroxylase and catechol-O-methyltransferase gene polymorphisms: Relationships to monoamine metabolite concentrations in CSF of healthy volunteers. Eur Arch Psychiatry Clin Neurosci 1997;247:297–302.
  14. Pecins-Thompson M, Brown NA, Kohama SG, Bethea CL: Ovarian steroid regulation of tryptophan hydroxylase mRNA expression in rhesus macaques. J Neurosci 1996;16:7021–7029.
  15. Tsai SJ, Wang YC, Hong CJ: Allelic variants of the alpha1a adrenoceptor and the promoter region of the α2a adrenoceptor and temperament factors. Am J Med Genet 2001;105:96–98.
  16. Tsai SJ, Wang YC, Hong CJ: Norepinephrine transporter and α2c adrenoceptor allelic variants and personality factors. Am J Med Genet 2002;114:649–651.
  17. Tsai SJ, Hong CJ, Cheng CY: Serotonin transporter genetic polymorphisms and harm avoidance in the Chinese. Psychiatr Genet 2002;12:165–168.
  18. Limson R, Goldman D, Roy A, Lamparski D, Ravitz B, Adinoff B, Linnoila M: Personality and cerebrospinal fluid monoamine metabolites in alcoholics and controls. Arch Gen Psychiatry 1991;48:437–441.
  19. Howard MO, Kivlahan D, Walker RD: Cloninger’s tridimensional theory of personality and psychopathology: Application to substance use disorders. J Stud Alcohol 1997;58:48–66.


Pay-per-View Options
Direct payment This item at the regular price: USD 33.00
Payment from account With a Karger Pay-per-View account (down payment USD 150) you profit from a special rate for this and other single items.
This item at the discounted price: USD 23.00