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Risk Factors of Stroke Mortality: A 40-Year Follow-Up of the Corfu Cohort from the Seven-Countries Study

Panagiotakos D.P.a · Chrysohoou C.a · Pitsavos C.a · Menotti A.c · Dontas A.b · Skoumas J.a · Stefanadis C.a · Toutouzas P.a
aCardiology Department, School of Medicine, University of Athens and bCentre of Studies of Age-Related Changes in Man, Athens, Greece; cAssociation for Cardiac Research, Rome, Italy Neuroepidemiology 2003;22:332–338 (DOI:10.1159/000072922)


The present work evaluates several risk factors for stroke mortality based on a 40-year follow-up of the Corfu cohort from the Seven-Countries Study. The population studied in this analysis consisted of 529 rural men (49.7 ± 5.7 years old) enrolled at 1961. The death rate at the end of follow-up was 87.1% (i.e. 461 deaths out of 529 participants). Of 529 cardiovascular-disease-free men at entry, 74 (14%) died because of hemorrhagic or thrombotic stroke. Age (HR = 1.11/year, p < 0.001), pulse pressure (HR = 1.16/5 mm Hg, p < 0.001), total serum cholesterol levels (HR = 0.81/10 mg/dl, p < 0.01) and presence of physical activity (HR = 0.59, p < 0.05), showed a statistically significant association with fatal stroke events. In conclusion, age, pulse pressure levels, physical activity (protective) and total serum cholesterol levels (protective) were significantly related with 40-year stroke mortality.


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