Table of Contents
To view the fulltext, log-in or choose pay-per-view options:
Get Access

Ifosfamide in the Adjuvant Therapy of Soft Tissue Sarcomas

Frustaci S.a · De Paoli A.b · Bidoli E.c · La Mura N.a · Berretta M.a · Buonadonna A.a · Boz G.b · Gherlinzoni F.d
Departments of aMedical Oncology, bRadiation Oncology and cEpidemiology and Biostatistics, Centro di Riferimento Oncologico di Aviano and dDivision of Orthopedics, General Hospital, Gorizia,Italy Oncology 2003;65(suppl 2):80–84 (DOI:10.1159/000073366)


Ifosfamide and anthracyclines are the only active agents in advanced soft tissue sarcomas. Doxorubicin was always used in sarcomas, whereas ifosfamide was reintroduced in the clinic after the discovery of mesna which prevents its typical dose-limiting toxicity: hemorrhagic cystitis. In the adjuvant setting, doxorubicin was used alone or in combination in the first-generation trials, whereas its parent compounds epirubicin and ifosfamide were employed in the second-generation adjuvant trials, which started in the early 90s. Other relevant aspects of the second-generation trials are the use of the hematopoietic growth factors and the increase of the dose intensity, the introduction of more restrictive selection criteria and the use of the two most active agents, ifosfamide and anthracyclines. Only the Italian cooperative trial has been concluded, and the results reported and updated. After a median follow-up of 89.6 months (range 56–119), the intention-to-treat analysis still reveals a difference in overall survival which, however, is not statistically significant. However, the 5-year overall survival estimate, which is a reasonable end point for the survival analysis of adjuvant treatment in soft tissue sarcomas, was 66.0 and 46.1% for the treatment and the control groups, respectively (p = 0.04).


Individual Users: Register with Karger Login Information

Please create your User ID & Password

Contact Information

I have read the Karger Terms and Conditions and agree.

Pay-per-View Options
Direct payment This item at the regular price: USD 38.00
Payment from account With a Karger Pay-per-View account (down payment USD 150) you profit from a special rate for this and other single items.
This item at the discounted price: USD 26.50