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Vol. 33, No. 2, 2003
Issue release date: March–April 2003 (November 2003)
Pathophysiol Haemost Thromb 2003;33:59–63

A Prospective Controlled Study of a Computer-Assisted Acenocoumarol Dosage Program

Marco F.b · Sedano C.a · Bermúdez A.a · López-Duarte M.a · Fernández-Fontecha E.a · Zubizarreta A.a
aServicio de Hematología del Hospital Universitario ‘Marqués de Valdecilla’, Universidad de Cantabria, Santander, bServicio de Hematología, Hospital de Basurto, Bilbao, Spain
email Corresponding Author

 goto top of outline Key Words

  • Oral anticoagulants
  • Computer-assisted dosage
  • Therapeutic quality
  • Acenocoumarol
  • International normalised ratio

 goto top of outline Abstract

The increase in oral anticoagulant (OA) treatment has led to development of new strategies for its control. We tested the efficacy of the GAO software (Dade Behring) in providing adequate acenocoumarol dosages for patients whose international normalised ratios (INRs) were no more than 0.5 points out of range. From December 1998 to August 1999, all outpatients in this setting were randomly assigned to receive computer-generated or traditionally fixed OA doses. Patients in their first 4 weeks of treatment were excluded. Overall, 8,352 dosages were calculated by the computer and 7,586 by the medical staff. The main endpoint of the study was the time spent in target INR range. The computer matched the traditional dosing, achieving a small but statistically significant greater efficacy in maintaining patients within the INR target range. The percentage of INR determinations over 5.5 was very low in both groups. Our results validate the computerised acenocoumarol dosing in our centre, achieving at least similar levels of effectiveness and safety compared with traditional dosage by medical staff.

Copyright © 2003 S. Karger AG, Basel

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 goto top of outline Author Contacts

Fernando Marco
Servicio de Hematología, Hospital de Basurto
Avenida Montevideo s/n. 48008 Bilbao (Spain)
Tel. +34 944006001, Fax +34 944006188

 goto top of outline Article Information

Received: April 25, 2002
Accepted after revision: April 7, 2003
Number of Print Pages : 5
Number of Figures : 2, Number of Tables : 3, Number of References : 24

 goto top of outline Publication Details

Pathophysiology of Haemostasis and Thrombosis
(Formely: Haemostasis)
Official Journal of the ‘Mediterranean League against Thromboembolic Diseases’

Vol. 33, No. 2, Year 2003 (Cover Date: March-April 2003 (Released November 2003))

Journal Editor: J. Rosing, Maastricht
ISSN: 1424–8832 (print), 1424–8840 (Online)

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