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Vol. 17, No. 1, 2004
Issue release date: January–February 2004
Skin Pharmacol Physiol 2004;17:42–48
(DOI:10.1159/000074062)

Photoprotection by Cichorium endivia Extracts: Prevention of UVB-Induced Erythema, Pyrimidine Dimer Formation and IL-6 Expression

Enk C.D. · Hochberg M. · Torres A. · Lev O. · Dor I. · Srebnik M. · Dembitsky V.M.
aDepartment of Dermatology, Hadassah University Hospital, Ein Kerem; bDepartment of Medicinal Chemistry and Natural Products, School of Pharmacy, Hebrew University of Jerusalem, and cDepartment of Environmental Science, Hebrew University of Jerusalem, Jerusalem, Israel

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Abstract

In the gradual process of evolution, plants have developed natural sun protecting substances that enable continuous survival under direct and intense ultraviolet (UV) radiation. As part of our studies of plant-derived pigments that might constitute an alternative to conventional sunscreens, we have tested the ethanolic extracts of roots, stalks, and inflorescences of populations of wild Cichorium endivia subsp. divaricatum (Asteraceae) in terms of protection against sunburn, and in prevention of UVB-induced pyrimidine dimer formation and IL-6 mRNA expression in the human keratinocyte cell line, HaCaT. Using ELISA technique for detection of pyrimidine dimers and RT-PCR for detection of IL-6, we found that the ethanolic extract of C. endivia roots absorbs radiation in the UVB spectrum and partially prevents induction of pyrimidine dimers and IL-6 expression. Application of the root extract on the skin prior to UVB irradiation totally prevented erythema. Our findings suggest that C. endivia extracts might possess sun-protective qualities that make them useful as sunscreens.



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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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    External Resources

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