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Table of Contents
Vol. 50, No. 1, 2004
Issue release date: January–February 2004
Section title: Paper
Gerontology 2004;50:39–43
(DOI:10.1159/000074388)

MMSE Cross-Domain Variability Predicts Cognitive Decline in Centenarians

Kliegel M. · Sliwinski M.
aInstitute of Psychology, Department of Gerontopsychology, University of Zurich, Zurich, Switzerland; bDepartment of Psychology, Syracuse University, Syracuse, N.Y., USA

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 12/10/2003

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 1

ISSN: 0304-324X (Print)
eISSN: 1423-0003 (Online)

For additional information: http://www.karger.com/GER

Abstract

Background: Early detection of dementia is one of the key issues in cognitive gerontology. However, so far the detection of early stages in cognitive decline has been rather unreliable. One central limitation of current assessment strategies is that they rely on information about a person’s level of performance obtained from a single assessment. Objective: In the first part of the present paper, we propose three strategies for overcoming this limitation by using information from several measurement occasions to improve diagnostic reliability. Methods: In the second part, we present one exemplary empirical analysis of one of these approaches reporting data from the Heidelberg Centenarian Study. Results: In this sample of very old individuals tested at baseline and at a follow-up 18 months later, the intra-individual cross-domain variability across MMSE subscales [1]at baseline predicted cognitive decline (i.e. change in an external cognitive functioning rating from baseline to follow-up) much better than baseline mean MMSE scores. Conclusions: In conclusion, we discuss the advantage of performance varibility as a predictor for cognitive decline.


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 12/10/2003

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 1

ISSN: 0304-324X (Print)
eISSN: 1423-0003 (Online)

For additional information: http://www.karger.com/GER


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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