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Vol. 176, No. 1-3, 2004
Issue release date: 2004
Cells Tissues Organs 2004;176:67–78

Forming a Multinucleated Cell: Molecules That Regulate Myoblast Fusion

Horsley V. · Pavlath G.K.
Department of Pharmacology, Emory University, Atlanta, Ga., USA

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In mammals, cell fusion occurs among a limited number of cell types: sperm and oocytes during fertilization, trophoblasts during placenta formation, macrophages during giant cell and osteoclast formation and myoblasts in the formation of myofibers and myotubes. The molecular mechanisms involved in these membrane fusion events largely are unknown. This review will focus on the known molecules that regulate myoblast fusion with an emphasis on a novel signaling pathway involving the calcium-regulated transcription factor NFATC2 in the regulation of myoblast fusion.

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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  128. Zalin, R.J. (1977) Prostaglandins and myoblast fusion. Dev Biol 59: 241–248.

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