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Vol. 133, No. 1, 2004
Issue release date: January 2004
Section title: Original Paper
Int Arch Allergy Immunol 2004;133:14–18
(DOI:10.1159/000075249)

Bronchial Hyperreactivity and Spirometric Impairment in Patients with Perennial Allergic Rhinitis

Ciprandi G. · Cirillo I. · Tosca M.A. · Vizzaccaro A.
aAllergy, Head and Neck Department, San Martino Hospital, Genoa, and bMedicine Department, Navy Hospital, La Spezia, Italy

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 5/5/2003
Accepted: 7/23/2003
Published online: 2/5/2004

Number of Print Pages: 5
Number of Figures: 5
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

Background: Allergic disorders are characterized by a systemic involvement of the immune response. There is a clear link between allergic rhinitis and asthma. Bronchial hyperreactivity (BHR) may be present in rhinitics. Smaller airways may also be impaired in mild asthma. This study aimed at evaluating a group of subjects suffering from perennial allergic rhinitis alone to investigate the presence of BHR and spirometric impairment. Methods: One hundred rhinitics sensitized only to perennial allergens were evaluated. Spirometry and methacholine bronchial challenge were performed. Results: Five rhinitics showed reduced values of forced expiratory volume/1 s (FEV1) without symptoms of asthma. Forty-eight rhinitics had reduced forced expiratory flow at 25 and 75% of pulmonary volume (FEF25–75) values. Seventy-two patients showed a positive methacholine challenge. In this group, reduced values of FVC (p < 0.05), FEV1 (p < 0.05), and FEF25–75 (p < 0.01) were demonstrated in comparison with BHR-negative rhinitics. There was a relationship between the degree of BHR and FEV1 values (p < 0.05) and FEF25–75 values (p < 0.01). Conclusions: This study evidences that an impairment of spirometric parameters may be observed in patients with perennial allergic rhinitis alone. A high percentage of these patients have BHR. Thus, new management strategies should be employed in rhinitics.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 5/5/2003
Accepted: 7/23/2003
Published online: 2/5/2004

Number of Print Pages: 5
Number of Figures: 5
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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References

  1. Van Cauwenberger P, De Belder T, Vermeiren J, Kaplan A: Global resources in allergy (GLORIA): Allergic rhinitis and conjunctivitis. Clin Exp Allergy Rev 2003;3:46–50.

    External Resources

  2. Johansson SGO, Hourihane JOB, Bousquet J, et al: A revised nomenclature for allergy. An EAACI position statement from the EAACI nomenclature task force. Allergy 2001;56:813–824.
  3. Plaschke PP, Janson C, Norrman E, et al: Onset and remission of allergic rhinitis and asthma and the relationship with atopic sensitization and smoking. Am J Respir Crit Care 2000;162:920–924.
  4. Pederson PA, Weeke ER: Asthma and allergic rhinitis in the same patients. Allergy 1983;38:25–29.
  5. Settipane GA: Allergic rhinitis – Update. Otolaryngol Head Neck Surg 1986;94:470–475.
  6. Beasly R: ISAAC-Phase I results: Global comparison (abstract). Eur Respir Soc 1997;10:134.
  7. Ciprandi G, Vizzaccaro A, Cirillo I, et al: Increase of asthma and allergic rhinitis prevalence in young Italian men. Int Arch Allergy Immunol 1996;111:279–283.
  8. Beers MH, Berkow R: The Merck Manual of Diagnosis and Therapy, ed 17. Whitehouse Station, Merck Research Laboratories, 1999, pp 521–532.
  9. Hamid Q, Song Y, Kotsimbos TC, et al: Inflammation of small airways in asthma. J Allergy Clin Immunol 1997;100:44–51.
  10. Bjermer L: History and future perspectives of treating asthma as a systemic and small airways disease. Respir Med 2001;95:703–719.
  11. Lipworth BJ, Clark DJ: Effects of airway calibre on lung delivery of nebulised salbutamol. Thorax 1997;52:1016–1023.
  12. Katelaris CH: Allergic rhinitis and asthma: Epidemiological evidence for the link. Clin Exp Allergy Rev 2003;3:5–8.

    External Resources

  13. Townley RG, Ryo UY, Kolotkin BM, Kang B: Bronchial sensitivity to methacholine in current and former asthmatic and allergic rhinitis patients and control subjects. J Allergy Clin Immunol 1975;56:429–442.
  14. Braman SS, Barrows AA, DeCotis BA, et al: Airways hyper-responsiveness in allergic rhinitis. A risk factor for asthma. Chest 1987;91:671–674.
  15. Verdiani P, Di Carlo S, Baronti A: Different prevalence and degree of nonspecific bronchial hyperreactivity in rhinitis. J Allergy Clin Immunol 1990;86:576–582.
  16. Società Italiana di Allergologia e Immunologia Clinica: Memorandum della Diagnostica delle Allergopatie. Fed Med 1987;40:861–874.
  17. Quanjer PH, Tammeling GJ, Cotes JE, Pedersen OF, Peslin R, Yernault J-C: Standardized lung function testing. Eur Respir J 1993;6:1–99.

    External Resources

  18. Global Initiative for Asthma: Pocket Guide for Asthma Management and Prevention. Bethesda, National Heart, Lung and Blood Institute, National Institute of Health, 1997, NIH Publication No 96-3659B.
  19. Simons FER: What’s in a name? The allergic rhinitis-asthma connection. Clin Exp Allergy Rev 2003;3:9–17.

    External Resources

  20. Guerra S, Sherrill DL, Martinez FD, Barbee RA: Rhinitis as an independent risk factor for adult-onset asthma. J Allergy Clin Immunol 2002;109:419–425.
  21. Riccio AM, Tosca MA, Cosentino C, et al: Cytokine pattern in allergic and non-allergic chronic rhinosinusitis in asthmatic children. Clin Exp Allergy 2002;32:422–426.
  22. Wagner EM, Liu MC, Weinmann GG, et al: Peripheral lung resistance in normal and asthmatic subjects. Am Rev Respir Dis 1990;141:584–588.
  23. Stahl E: Correlation between objective measures of airway calibre and clinical symptoms in asthma: A systematic review of clinical studies. Respir Med 2000;94:735–741.
  24. Ciprandi G, Pronzato C, Ricca V, et al: Allergen-specific challenge induces ICAM-1 on nasal epithelial cells in allergic subjects. Am J Respir Crit Care 1994;150:1653–1659.
  25. Crimi E, Milanese M, Oddera S, et al: Inflammatory and mechanical factors of allergen-induced bronchoconstriction in mild asthma and rhinitis. J Appl Physiol 2001;91:1029–1034.
  26. Eng PA, Reinhold M, Gnehm HPE: Long-term efficacy of preseasonal grass pollen immunotherapy in children. Allergy 2002;57:306–312.
  27. Bousquet J: Requirements for medication commonly used in the treatment of allergic rhinitis. Allergy 2003,58:192–197.
  28. ETAC Study Group: Allergic factors associated with the development of asthma and the influence of cetirizine in a double-blind, randomized, placebo-controlled trial: First results of ETAC. Pediatr Allergy Immunol 1998;3:116–124.