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Vol. 49, No. 1, 2004
Issue release date: January 2004
Section title: Biological Psychiatry. Editor: J. Mendlewicz (Brussels) / Original Paper
Neuropsychobiology 2004;49:24–29
(DOI:10.1159/000075335)

Psychobiological Aspects of Somatoform Disorders: Contributions of Monoaminergic Transmitter Systems

Rief W. · Pilger F. · Ihle D. · Verkerk R. · Scharpe S. · Maes M.
aCenter for Behavioral Medicine, Klinik Roseneck, Prien am Chiemsee, and bDepartment of Clinical Psychology and Psychotherapy, University of Marburg, Marburg, Germany; cDepartment of Medical Biochemistry, University of Antwerp, Edegem, Belgium; dDepartment of Psychiatry and Neuropsychology, University Hospital of Maastricht, Maastricht, The Netherlands

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Article / Publication Details

First-Page Preview
Abstract of Biological Psychiatry. Editor: J. Mendlewicz (Brussels) / Original Paper

Published online: 1/22/2004

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 1

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS

Abstract

Objective: To evaluate the possible biological aspects of ‘unexplained physical symptoms’, this study examined serotonergic and noradrenergic monoamino acids in somatoform disorders and/or depression. Methods: Blood samples of 150 subjects from 4 groups (somatization syndrome; depression; depression and somatization; controls) were analyzed for amino acids contributing to the serotonergic and noradrenergic system and peripheral muscle energy balance (tryptophan, valine, leucine, isoleucine, phenylalanine and tyrosine). Results: Tryptophan, branched chain amino acids and other serotonergic amino acids were decreased in patients with somatoform symptoms, even when no depression was present. Conclusions: We conclude that serotonergic amino acids are biological correlates of multiple unexplained symptoms. Ways of action do not only involve brain mechanisms, but also energy metabolism in peripheral muscles.


Article / Publication Details

First-Page Preview
Abstract of Biological Psychiatry. Editor: J. Mendlewicz (Brussels) / Original Paper

Published online: 1/22/2004

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 1

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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