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Vol. 49, No. 1, 2004
Issue release date: January 2004
Neuropsychobiology 2004;49:38–41

Association between Major Depressive Disorder and the –1438A/G Polymorphism of the Serotonin 2A Receptor Gene

Choi M.-J. · Lee H.-J. · Lee H.-J. · Ham B.-J. · Cha J.-H. · Ryu S.-H. · Lee M.-S.
Departments of aPsychiatry, Korea University College of Medicine, bMedical Sciences, Korea University Graduate School, cYong-In Psychiatric Research Institute, and dPsychiatry, Konkuk University Medical College, Seoul, Korea

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This study investigated the possible effect of the –1438A/G single-nucleotide polymorphism in the promoter region of the serotonin 2A receptor (5-HTR2A) gene on major depressive disorder (MDD) in a Korean population. This polymorphism was analyzed in 189 patients with MDD and in 148 unrelated healthy controls using a case-control design, which revealed a significant difference in the genotype distributions (χ2 = 10.78, d.f. = 2, p = 0.005). The frequency of the –1438G allele was also much higher in MDD patients than in normal controls (χ2 = 7.20, p = 0.007; OR = 1.52, 95% CI 1.12–2.06). We also found significantly more carriers of the G allele (GG+AG genotypes) in MDD patients than in normal controls (χ2 = 10.18, p = 0.001; OR = 2.46, 95% CI 1.40–4.32). Our results support the hypothesis that the –1438A/G polymorphism of the promoter region of the 5-HTR2A gene is associated with MDD patients in a Korean population.

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