Journal Mobile Options
Table of Contents
Vol. 48, No. 2, 2004
Issue release date: March–April 2004
Section title: Review
Ann Nutr Metab 2004;48:61–66
(DOI:10.1159/000075591)

Influence of Trans Fatty Acids on Health

Stender S. · Dyerberg J.
Danish Nutrition Council,aDepartment of Clinical Biochemistry, Gentofte Hospital, University of Copenhagen, and bInstitute of Human Nutrition, Royal Veterinary and Agricultural University, Frederiksberg, Denmark

Do you have an account?

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger (new!)
  • Unrestricted printing, no saving restrictions for personal use
  • Reduced rates with a PPV account
read more

Direct: USD 38.00
Account: USD 26.50

Select

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restriction apply

Rental: USD 8.50
Cloud: USD 20.00

Select

Subscribe

  • Automatic perpetual access to all articles of the subscribed year(s)
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select


Article / Publication Details

First-Page Preview
Abstract of Review

Received: 3/5/2003
Accepted: 6/10/2003
Published online: 4/21/2004

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM

Abstract

The contribution of dietary trans fatty acids (TFAs) on the risk of ischemic heart disease (IHD) has recently gained further support due to the results from large, prospective, population-based studies. Compared to saturated fat, TFAs are, gram to gram, associated with a considerably (2.5- to >10-fold) higher risk increment for IHD. A negative effect on the human fetus and on newborns and an increase in colon cancer risk in adults are possible but, however, still equivocal. Recent findings justify further studies concerning the effect of TFAs on allergic diseases in children and on the risk of type-2 diabetes in adults. The intake of industrially produced TFAs in European countries is decreasing. However, determination of the TFA content in various popular food items collected in Danish shops showed that it is likely that persons with a frequent intake of, e.g., French fries, microwave oven popcorn, chocolate bars, fast food, etc., consume industrially produced TFAs in amounts far exceeding the average intake, and are thereby exposed to an unnecessary health risk. The Danish government has decided that oils and fats containing more than 2% industrially produced TFAs will not be sold in Denmark after the January 1, 2004.


Article / Publication Details

First-Page Preview
Abstract of Review

Received: 3/5/2003
Accepted: 6/10/2003
Published online: 4/21/2004

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

References

  1. Aro A: Complexity of issue of dietary trans fatty acid. Lancet 2001;357:732–733.
  2. Aro A, Kardinaal AF, Salminen I, Kark JD, Riemersma RA, Delgado-Rodriguez M, Gomez-Aracena J, Huttunen JK, Kohlmeier L, Martin BC, Martin-Moreno JM, Mazaev VP, Ringstad J, Thamm M, van‘t Veer P, Kok FJ: Adipose tissue isomeric trans fatty acids and risk of myocardial infarction in nine countries: The EURAMIC study. Lancet 1995;345:273–278.
  3. Aro A: Epidemiology of trans fatty acids and coronary heart disease in Europe. Nutr Metab Cardiovasc Dis 1998;8:402–407.
  4. Pedersen JI, Ringstad J, Almendingen K, Haugen TS, Stensvold I, Thelle DS: Adipose tissue fatty acids and risk of myocardial infarction – A case-control study. Eur J Clin Nutr 2000;54:618–625.
  5. Ascherio A, Rimm EB, Giovannucci EL, Spiegelman D, Stampfer M, Willett WC: Dietary fat and risk of coronary heart disease in men: Cohort follow up study in the United States. BMJ 1996;313:84–90.
  6. Pietinen P, Ascherio A, Korhonen P, Hartman AM, Willett WC, Albanes D, Virtamo J: Intake of fatty acids and risk of coronary heart disease in a cohort of Finnish men. The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Am J Epidemiol 1997;145:876–887.
  7. Hu FB, Stampfer MJ, Manson JE, Rimm E, Colditz GA, Rosner BA, Hennekens CH, Willett WC: Dietary fat intake and the risk of coronary heart disease in women. N Engl J Med 1997;337:1491–1499.
  8. Oomen CM, Ocké MC, Feskens EJM, van Erp-Baart MJ, Kok FJ, Kromhout D: Association between trans fatty acid intake and 10-year risk of coronary heart disease in the Zutphen Elderly Study: A prospective population-based study. Lancet 2001;357:746–751.
  9. Ascherio A, Katan MB, Zock PL, Stampfer MJ, Willett WC: Trans fatty acids and coronary heart disease. N Engl J Med 1999;340:1994–1998.
  10. Ascherio A, Rimm EB, Giovannucci EL, Spiegelman D, Stampfer M, Willett WC: Dietary fat and risk of coronary heart disease in men: Cohort follow up study in the United States. BMJ 1996;313:84–90.
  11. Clevidence BA, Judd JT, Schaefer EJ, Jenner JL, Lichtenstein AH, Muesing RA, Wittes J, Sunkin ME: Plasma lipoprotein(a) levels in men and women consuming diets enriched in saturated, cis-, or trans-monounsaturated fatty acids. Arterioscler Thromb Vasc Biol 1997;17:1657–1661.
  12. Hokanson JE, Austin MA: Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: A meta-analysis of population based prospective studies. J Cardiovasc Risk 1996:213–219.
  13. de Roos NM, Bots ML, Katan MB: Replacement of dietary saturated fatty acids by trans fatty acids lowers serum HDL cholesterol and impairs endothelial function in healthy men and women. Arterioscler Thromb Vasc Biol 2001;21:1233–1237.
  14. GISSI-Prevenzione Investigators: Dietary supplementation with n–3 poly-unsaturated fatty acids and vitamin E after myocardial infarction: Results of the GISSI-Prevenzione trial. Lancet 1999;354:447–455.
  15. Wenzel DG, Kloepell JW: Incorporation of saturated and cis and trans unsaturated long-chain fatty acids in rat myocytes and increased susceptibility to arrhythmias. Toxicology 1980;18:27–36.
  16. Leaf A: The electrophysiological basis for the antiarrhythmic actions of polyunsaturated fatty acids. Eur Heart J 2001;3(suppl):D98–D105.
  17. Lemaitre RN, King IB, Raghunathan TE, Pearce RM, Weinmann S, Knopp RH, Copass MK, Cobb LA, Siscovick DS: Cell membrane trans-fatty acids and the risk of primary cardiac arrest. Circulation 2002;105:697–701.
  18. Willett WC, Stampfer MJ, Manson JE, Colditz GA, Speizer FE, Rosner BA: Intake of trans fatty acids and risk of coronary heart diseases among women. Lancet 1993;341:581–585.
  19. Berghaus TM, Demmelmair H, Koletzko B: Fatty acid composition of lipid classes in maternal and cord plasma at birth. Eur J Pediatr 1998;157:763–768.
  20. Pax J, Douglass L, Sampugna J: Effects of linolenic and trans-fatty-acids on neonatal survival of C57BL/6 mice. J Nutr Biochem 1992;3:342–348.
  21. Koletzko B: TFA may impair biosynthesis of long-chain polyunsaturates and growth in man. Acta Paediatr 1992;81:302–306.

    External Resources

  22. Elias SL, Innis SM: Infant plasma trans, n–6, and n–3 fatty acids and conjugated linoleic acids are related to maternal plasma fatty acids, length of gestation, and birth weight and length. Am J Clin Nutr 2001;73:807–814.
  23. Decsi T, Burus I, Molnár S, Minda H, Veitl V: Inverse association between trans isomeric and long-chain polyunsaturated fatty acids in cord blood lipids of full-term infants. Am J Clin Nutr 2001;74:364–368.
  24. Olsen SF, Sorensen JD, Secher NJ, Hedegaard M, Henriksen TB, Hansen HS, Cerant A: Randomised controlled trial of effect of fish-oil supplementation on pregnancy duration. Lancet 1992;339:1003–1007.
  25. Williams MA, King IB, Sorensen TK, Zingheim RW, Troyer BL, Zebelman AM, Luthy DA: Risk of preeclampsia in relation to elaidic acid (trans fatty acid) in maternal erythrocytes. Gynecol Obstet Invest 1998;46:84–87.
  26. Bakker N, van’t Veer P, Zock PL, the Euramic Study Group: Adipose fatty acids and cancers of the breast, prostate and colon: An ecological study. Int J Cancer 1997;72:587–597.
  27. Kohlmeier L, Simonsen N, van’t Veer P, Strain JJ, Martin-Moreno JM, Margolin B, Hutterunen JK, Fernandez-Crehuet Navajas J, Martin BC, Thamm M, Kardinaal AFM, Kok FJ: Adipose tissue trans fatty acids and breast cancer in the European Community Multicenter Study on Antioxidants, Myocardial Infarction, and Breast Cancer. Cancer Epidemiol Biomarkers Prev 1997;6:705–710.
  28. Petrek JA, Hudgins LC, Ho M, Bajorumas DR, Hirsch J: Fatty acid composition of adipose tissue, and indication of dietary fatty acids, and breast cancer prognosis. J Clin Oncol 1997;15:1377–1384.
  29. Holmes MD, Hunter DJ, Colditz GA, Stampfer MJ, Hankinson SE, Speizer FE, Rosner B, Willet WC: Association of dietary intake of fat and fatty acids with risk of breast cancer. JAMA 1999;281:914–920.
  30. McKelvey W, Greenland S, Chen M-J, Longnecker MP, Frankl HD, Lee ER, Haile RW: A case-control study of colorectal adenomatous polyps and consumption of foods containing partially hydrogenated oils. Cancer Epidemiol 1999;8:519–524.
  31. Slattery ML, Benson J, Ma KN, Schaffer D, Potter JD: Trans-fatty acids and colon cancer. Nutr Cancer 2001;39:170–175.
  32. von Mutius E, Weiland SK, Fritzsch C, Duhme H, Keil U: Increasing prevalence of hay fever and atopy among children in Leipzig, East Germany. Lancet 1998;351:862–866.
  33. The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee: Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. Lancet 1998;351:1225–1232.
  34. Weiland SK, von Mutius E, Hüsing A, Asher MI: Intake of trans fatty acids and prevalence of childhood asthma and allergies in Europe. ISAAC Steering Committee. Lancet 1999;353:2040–2041.
  35. Salméron J, Hu FB, Manson JE, Stampfer MJ, Colditz GA, Rimm EB, Willett WC: Dietary fat intake and risk of type 2 diabetes in women. Am J Clin Nutr 2001;73:1019–1026.
  36. van Dam RM, Willett WC, Rimm EB, Stampfer MJ, Hu FB: Dietary fat and meat intake in relation to risk of type 2 diabetes in men. Diabetes Care 2001;25:417–424.
  37. Meyer KA, Kushi LH, Jacobs DR, Folsom AR: Dietary fat and incidence of type 2 diabetes in older Iowa women. Diabetes Care 2001;24:1528–1535.
  38. Bray GA, Lovejoy JC, Smith SR, DeLany JP, Lefevre M, Hwang D, Ryan DH, York DA: The Influence of different fats and fatty acids on obesity, insulin resistance and inflammation. J Nutr 2002;132:2488–2491.
  39. Christiansen E, Schnider S, Palmvig B, Tauber-Lassen E, Pedersen O: Intake of a diet high in trans monounsaturated fatty acids or saturated fatty acids. Effects on postprandial insulinemia and glycemia in obese patients with NIDDM. Diabetes Care 1997;20:881–887.
  40. Alstrup KK, Gregersen S, Jensen HM, Thomsen JL, Hermansen K: Differential effects of cis and trans fatty acids on insulin release from isolated mouse islets. Metabolism 1999;48:22–29.
  41. van Poppel G: Intake of trans fatty acids in western Europe: The TRANSFAIR Study. Lancet 1998;351:1099–1106.

    External Resources

  42. Stender S, Dyerberg J, Hølmer G, Ovesen L, Sandstrøm B: The influence of trans fatty acids on health: A report from the Danish Nutrition Council. Clin Sci (Lond) 1995;88:375–392.
  43. Hansen K, Leth T: Overvågning af margarine. Ministeriet for Fødevarer, Landbrug og Fiskeri., København, Fødevaredirektoratet, 2000.
  44. Stender S, Dyerberg J: Transfedtsyrers betydning for sundheden – opdatering år 2001. En rapport fra Ernæringsrådet. Publ. nr. 23. København, 2001.
  45. Litin L, Sacks F: Trans-fatty-acid content of common foods. N Engl J Med 1993;329:1969–1970.
  46. Canada sets new nutrition labelling standards. Inform AOCS 2003;14:57–104.
  47. Federal Register Rules and Regulations. Food labelling; trans fatty acids in nutrition labelling. Nutrient Content Claims and Health Claims 2003;69:41433–41506.
  48. Letter Report on Dietary Reference Intakes for Trans Fatty Acids. Washington, National Academy Press, 2002.
  49. Kromhout D, Menotti A, Bloemberg B, Aravanis C, Blackburn H, Buzina R, Dontas AS, Fidanza F, Giaipaoli S, Jansen A, et al: Dietary saturated and trans fatty acids and cholesterol and 25-year mortality from coronary heart disease: The Seven Countries Study. Prev Med 1995;24:308–315.
  50. Thom TJ, Epstein FH: Heart disease, cancer, and stroke mortality. Trends and their interrelations. An international perspective. Circulation 1994;90:574–582.
  51. Zegarska Z, Borejszo Z: Trans fatty acid content of some food products in Poland. J Food Lipids 2001;8:271–279.
  52. Katz AM: Trans-fatty acids and sudden cardiac death. Circulation 2002;105:569–571.

    External Resources