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Med Princ Pract 2004;13:69–73

Primary Malignant Tumors of the Trachea – The Tata Memorial Hospital Experience

Thotathil Z.S.a · Agarwal J.P.b · Shrivastava S.K.b · Dinshaw K.A.b
aDepartment of Radiation Oncology, Husain Maki Al Juma Center for Surgery, Kuwait; bDepartment of Radiation Oncology, Tata Memorial Hospital, Parel, Mumbai, India
email Corresponding Author

 goto top of outline Key Words

  • Trachea
  • Neoplasms
  • Malignant tracheal tumors
  • Therapy

 goto top of outline Abstract

Objective: Primary tumors of the trachea are extremely rare. Treatment methods vary considerably and few studies have sought to provide adequate guidelines. This study reviews the records of patients treated for tracheal cancer at the Tata Memorial Hospital (TMH), Mumbai, India. Subjects and Methods: Fifteen patients with primary tracheal malignancies were identified in the TMH database during the period from 1983 to 2000. They were predominantly males (87%) belonging to an older age-group (67% above 40 years). Common presenting symptoms were cough, hoarseness, hemoptysis and indications of airway obstruction. Squamous cell carcinoma was the commonest histologic subtype (40%) followed by adenoid cystic carcinoma (27%). Ten patients received radical treatment. One patient underwent surgery (resection and anastomosis) and received postoperative radiotherapy. Another was explored but was found to be unresectable and was 1 of 2 patients treated with chemotherapy and radiotherapy. Laser resections and radiotherapy were used in 2 patients while 4 patients were managed with radiotherapy alone. One patient was treated elsewhere. The majority of patients (8/9) were treated with locoregional fields and doses ranging from 40 to 60 Gy (median 50 Gy). Two patients also received intraluminal brachytherapy, 1 as part of initial treatment and another for recurrence. Results: Only 5 patients treated at TMH (5/9) achieved local control of their disease. Follow-up times ranged from 1 month to 134 months, median of 38 months. Distant metastases were identified in 4 patients (bone n = 1 and lung n = 3). Median survival was 38 months. Overall survival at 5 years was 37% by Kaplan-Meier method, but this figure should be treated with caution since only 6 patients had a follow-up of more than 2 years. Conclusion: Tracheal cancer is a rare malignancy. Radiation therapy is a reasonably effective modality for unresectable disease.

Copyright © 2004 S. Karger AG, Basel

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 goto top of outline Author Contacts

Dr. Ziad S. Thotathil
PO Box 39433
73055 Nuzha (Kuwait)
Tel. +965 796 0199, Fax +965 481 3724

 goto top of outline Article Information

Received: September 28, 2002
Revised: April 26, 2003
Number of Print Pages : 5
Number of Figures : 1, Number of Tables : 2, Number of References : 25

 goto top of outline Publication Details

Medical Principles and Practice
A Publication of the Academic Publications Council

Vol. 13, No. 2, Year 2004 (Cover Date: March-April 2004)

Journal Editor: Farida Al Awadi, Kuwait
ISSN: 1011–7571 (print), 1423–0151 (Online)

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